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Literature summary extracted from
- Flavin mono-oxygenase (FMO) - The other oxidase (2008), Curr. Drug Metab., 9, 280-284.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.13.8 | five genes encoding isozymes FMO1-FMO5 and 1 pseudogene organized in a gene cluster | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.14.13.8 | down | FMO5 is downregulated in type II diabetes in liver. FMO1 downregulation and inhibition by 3,3'-diindolylmethane | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.8 | 3,3'-diindolylmethane | competitive inhibition of FMO3 | Homo sapiens |  |
| 1.14.13.8 | indole-3-carbinol | competitive inhibition of FMO3 | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.13.8 | microsome | - |
Mus musculus | - |
- |
| 1.14.13.8 | microsome | - |
Homo sapiens | - |
- |
| 1.14.13.8 | microsome | - |
Rattus norvegicus | - |
- |
| 1.14.13.8 | microsome | - |
Sus scrofa | - |
- |
| 1.14.13.8 | microsome | - |
Oryctolagus cuniculus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.8 | additional information | Homo sapiens | the enzyme is regulated by hormones, e.g. testosterone | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.13.8 | Homo sapiens | - |
- |
- |
| 1.14.13.8 | Mus musculus | - |
- |
- |
| 1.14.13.8 | Oryctolagus cuniculus | - |
- |
- |
| 1.14.13.8 | Rattus norvegicus | - |
- |
- |
| 1.14.13.8 | Sus scrofa | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.13.8 | native enzyme from liver microsomes | Sus scrofa |
| 1.14.13.8 | native enzyme from lung microsomes | Oryctolagus cuniculus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.13.8 | liver | - |
Mus musculus | - |
| 1.14.13.8 | liver | - |
Sus scrofa | - |
| 1.14.13.8 | liver | FMO1 is the major isozyme in liver | Homo sapiens | - |
| 1.14.13.8 | liver | FMO1 is the major isozyme in liver | Rattus norvegicus | - |
| 1.14.13.8 | lung | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.8 | methimazole + NADPH + H+ + O2 | N-oxidation | Homo sapiens | methimazole N-oxide + NADP+ + H2O | - |
? | |
| 1.14.13.8 | additional information | the enzyme is regulated by hormones, e.g. testosterone | Homo sapiens | ? | - |
? | |
| 1.14.13.8 | thiobenzamide + NADPH + H+ + O2 | N-oxidation | Homo sapiens | thiobenzamide N-oxide + NADP+ + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.13.8 | flavin mono-oxygenase | - |
Mus musculus |
| 1.14.13.8 | flavin mono-oxygenase | - |
Homo sapiens |
| 1.14.13.8 | flavin mono-oxygenase | - |
Rattus norvegicus |
| 1.14.13.8 | flavin mono-oxygenase | - |
Sus scrofa |
| 1.14.13.8 | flavin mono-oxygenase | - |
Oryctolagus cuniculus |
| 1.14.13.8 | FMO | - |
Mus musculus |
| 1.14.13.8 | FMO | - |
Homo sapiens |
| 1.14.13.8 | FMO | - |
Rattus norvegicus |
| 1.14.13.8 | FMO | - |
Sus scrofa |
| 1.14.13.8 | FMO | - |
Oryctolagus cuniculus |
| 1.14.13.8 | FMO1 | - |
Mus musculus |
| 1.14.13.8 | FMO1 | - |
Homo sapiens |
| 1.14.13.8 | FMO1 | - |
Rattus norvegicus |
| 1.14.13.8 | FMO1 | - |
Sus scrofa |
| 1.14.13.8 | FMO1 | - |
Oryctolagus cuniculus |
| 1.14.13.8 | FMO2 | - |
Mus musculus |
| 1.14.13.8 | FMO2 | - |
Homo sapiens |
| 1.14.13.8 | FMO2 | - |
Rattus norvegicus |
| 1.14.13.8 | FMO2 | - |
Sus scrofa |
| 1.14.13.8 | FMO2 | - |
Oryctolagus cuniculus |
| 1.14.13.8 | FMO3 | - |
Mus musculus |
| 1.14.13.8 | FMO3 | - |
Homo sapiens |
| 1.14.13.8 | FMO3 | - |
Rattus norvegicus |
| 1.14.13.8 | FMO3 | - |
Sus scrofa |
| 1.14.13.8 | FMO3 | - |
Oryctolagus cuniculus |
| 1.14.13.8 | FMO4 | - |
Mus musculus |
| 1.14.13.8 | FMO4 | - |
Homo sapiens |
| 1.14.13.8 | FMO4 | - |
Rattus norvegicus |
| 1.14.13.8 | FMO4 | - |
Sus scrofa |
| 1.14.13.8 | FMO4 | - |
Oryctolagus cuniculus |
| 1.14.13.8 | FMO5 | - |
Mus musculus |
| 1.14.13.8 | FMO5 | - |
Homo sapiens |
| 1.14.13.8 | FMO5 | - |
Rattus norvegicus |
| 1.14.13.8 | FMO5 | - |
Sus scrofa |
| 1.14.13.8 | FMO5 | - |
Oryctolagus cuniculus |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.14.13.8 | Rattus norvegicus | bacterial lipopolysaccharides lead to enzyme downregulation in the liver, as well as posttranslationally S-nitrosylation by nitric oxide | down |
| 1.14.13.8 | Oryctolagus cuniculus | downregulation of FMO1 and FMO3 by glucocorticoids and progesterone | down |
| 1.14.13.8 | Mus musculus | in female mice, testosterone plays a role in negative FMO regulation | down |
| 1.14.13.8 | Mus musculus | liver FMO1 is upregulated in diabetic mice | up |
| 1.14.13.8 | Rattus norvegicus | liver FMO1 is upregulated in diabetic rats | up |
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