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Literature summary extracted from

  • Ho, P.W.; Chu, A.C.; Kwok, K.H.; Liu, H.F.; Kung, M.H.; Ramsden, D.B.; Ho, S.L.
    Effects of plasticisers and related compounds on the expression of the soluble form of catechol-O-methyltransferase in MCF-7 cells (2008), Curr. Drug Metab., 9, 276-279.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.6 4-(tert-octyl)phenol causes significant inhibition of enzyme activity Homo sapiens
2.1.1.6 benzyl butyl phthalate causes significant inhibition of enzyme activity Homo sapiens
2.1.1.6 dibutyl phthalate causes significant inhibition of enzyme activity Homo sapiens
2.1.1.6 diisononyl phthalate causes significant inhibition of enzyme activity Homo sapiens
2.1.1.6 dioctyl phthalate causes significant inhibition of enzyme activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.6 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.6 MCF-7 cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
2.1.1.6 COMT
-
 Homo sapiens
2.1.1.6 S-COMT
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.1.1.6 Homo sapiens 4-(tert-octyl)phenol, benzyl butyl phthalate, diisononyl phthalate, dibutyl phthalate, and dioctyl phthalate inhibit S-COMT protein expression in MCF-7 cells at 72 h, the inhibitory effect is abolished in the presence of the anti-estrogen ICI182780 down