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Literature summary extracted from

  • Carro, M.D.; Falkenstein, E.; Radke, W.J.; Klandorf, H.
    Effects of allopurinol on uric acid concentrations, xanthine oxidoreductase activity and oxidative stress in broiler chickens (2009), Comp. Biochem. Physiol. C, 151, 12-17.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.17.1.4 allopurinol inhibits xanthine and hypoxanthine oxidation in vivo in intestine and pancreas, but enhances the activity in liver, tissue-dependent effects, overview Gallus gallus
1.17.3.2 allopurinol inhibits xanthine and hypoxanthine oxidation in vivo in intestine and pancreas, but enhances the activity in liver, tissue-dependent effects, overview Gallus gallus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.1.4 allopurinol inhibits xanthine and hypoxanthine oxidation in vivo in intestine and pancreas, but enhances the activity in liver, tissue-dependent effects, overview Gallus gallus
1.17.3.2 allopurinol inhibits xanthine and hypoxanthine oxidation in vivo in intestine and pancreas, but enhances the activity in liver, tissue-dependent effects, overview Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.1.4 hypoxanthine + NAD+ + H2O Gallus gallus
-
 xanthine + NADH + H+
-
 ?
1.17.1.4 xanthine + NAD+ + H2O Gallus gallus
-
 urate + NADH + H+
-
 ?
1.17.3.2 xanthine + O2 + H2O Gallus gallus
-
 urate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.4 Gallus gallus
-
 domesticus, male chicken
-
1.17.3.2 Gallus gallus
-
 domesticus, male chicken
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.1.4 intestine
-
 Gallus gallus
-
1.17.1.4 kidney
-
 Gallus gallus
-
1.17.1.4 liver
-
 Gallus gallus
-
1.17.1.4 pancreas
-
 Gallus gallus
-
1.17.3.2 intestine
-
 Gallus gallus
-
1.17.3.2 kidney
-
 Gallus gallus
-
1.17.3.2 liver
-
 Gallus gallus
-
1.17.3.2 pancreas
-
 Gallus gallus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.17.1.4 additional information
-
 tissue-dependent enzyme activity, overview Gallus gallus
1.17.1.4 17.5
-
 pancreas enzyme with allopurinol at 50 mg/kg body weight Gallus gallus
1.17.1.4 17.8
-
 pancreas enzyme Gallus gallus
1.17.1.4 25.2
-
 intestine enzyme with allopurinol at 50 mg/kg body weight Gallus gallus
1.17.1.4 26.6
-
 intestine enzyme Gallus gallus
1.17.1.4 29.5
-
 kidney enzyme with allopurinol at 50 mg/kg body weight Gallus gallus
1.17.1.4 49.9
-
 kidney enzyme Gallus gallus
1.17.3.2 additional information
-
 tissue-dependent enzyme activity, overview Gallus gallus
1.17.3.2 17.5
-
 pancreas enzyme with allopurinol at 50 mg/kg body weight Gallus gallus
1.17.3.2 17.8
-
 pancreas enzyme Gallus gallus
1.17.3.2 25.2
-
 intestine enzyme with allopurinol at 50 mg/kg body weight Gallus gallus
1.17.3.2 26.6
-
 intestine enzyme Gallus gallus
1.17.3.2 29.5
-
 kidney enzyme with allopurinol at 50 mg/kg body weight Gallus gallus
1.17.3.2 49.9
-
 kidney enzyme Gallus gallus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.4 hypoxanthine + NAD+ + H2O
-
 Gallus gallus xanthine + NADH + H+
-
 ?
1.17.1.4 xanthine + NAD+ + H2O
-
 Gallus gallus urate + NADH + H+
-
 ?
1.17.3.2 xanthine + O2 + H2O
-
 Gallus gallus urate + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.1.4 xanthine oxidoreductase
-
 Gallus gallus
1.17.1.4 XOR
-
 Gallus gallus
1.17.3.2 xanthine oxidoreductase
-
 Gallus gallus
1.17.3.2 XOR
-
 Gallus gallus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.17.1.4 41
-
 assay at Gallus gallus
1.17.3.2 41
-
 assay at Gallus gallus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.1.4 7.8
-
 assay at Gallus gallus
1.17.3.2 7.8
-
 assay at Gallus gallus

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.1.4 NAD+
-
 Gallus gallus