Literature summary extracted from

Mino, Y.; Naito, T.; Otsuka, A.; Ozono, S.; Kagawa, Y.; Kawakami, J.
Inosine monophosphate dehydrogenase activity depends on plasma concentrations of mycophenolic acid and its glucuronides in kidney transplant recipients (2009), Clin. Chim. Acta, 409, 56-61.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.1.1.205	mycophenolate mofetil	median IMPDH activity in erythrocytes is 1.73times higher in mycophenolate mofetil positive than in mycophenolate mofetil negative kidney transplant recipients. Predose IMPDH activity in erythrocytes is induced slowly by mycophenolate mofetil therapy and is dependent on mycophenolic acid, phenolic and acyl glucuronides in stable kidney transplant recipients	Homo sapiens

Application

EC Number	Application	Comment	Organism
1.1.1.205	medicine	IMPDH activity in erythrocytes may be useful indicator of short-term immunosuppression and long-term exposure of the immunosuppressant mycophenolic acid	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.205	Mycophenolic acid	IMPDH activity in erythrocytes is inhibited at the peak plasma concentration of mycophenolic acid in initial kidney transplant recipients. Reduction does not coincide with the peak of the plasma concentration of phenolic and acyl glucuronides of mycophenolic acid	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.205	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.205	erythrocyte	-	Homo sapiens	-

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.205	IMPDH	-	Homo sapiens
1.1.1.205	inosine monophosphate dehydrogenase	-	Homo sapiens

Expression

EC Number	Organism	Comment	Expression
1.1.1.205	Homo sapiens	increase in IMPDH activity in erythrocytes after kidney transplantation	up

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Release 2023.1 (January 2023)