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Literature summary extracted from

  • Sors, A.; Jean-Louis, F.; Begue, E.; Parmentier, L.; Dubertret, L.; Dreano, M.; Courtois, G.; Bachelez, H.; Michel, L.
    Inhibition of IkappaB kinase subunit 2 in cutaneous T-cell lymphoma down-regulates nuclear factor-kappaB constitutive activation, induces cell death, and potentiates the apoptotic response to antineoplastic chemotherapeutic agents (2008), Clin. Cancer Res., 14, 901-911.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.11.10 medicine IKK2 inhibition represents a promising strategy for the treatment of advanced stages of cutaneous T-cell lymphomas Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.10 additional information a vector expressing a mutant form of IKK2 is used, characterized by the substitution of two serine residues with alanines, leading to inhibition of IKK2 autophosphorylation required for IKK activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.10 AS602868
-
Homo sapiens
2.7.11.10 N-(3,5-bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein] Homo sapiens
-
ADP + [IkappaB phosphoprotein]
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.10 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.10 HUT-78 cell
-
Homo sapiens
-
2.7.11.10 JURKAT cell
-
Homo sapiens
-
2.7.11.10 MyLa 2059 cell mycosis fungoides cell line Homo sapiens
-
2.7.11.10 SeAx cell
-
Homo sapiens
-
2.7.11.10 T-cell lymphoma cell cutaneous T-cell lymphoma Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein]
-
Homo sapiens ADP + [IkappaB phosphoprotein]
-
?

Subunits

EC Number Subunits Comment Organism
2.7.11.10 heterotrimer IkappaB kinase, IKK, is composed of two catalytic subunits, IKK1 or IKKalpha and IKK2 or IKKbeta, and a regulatory subunit called NEMO or IKKgamma Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.11.10 IkappaB kinase
-
Homo sapiens
2.7.11.10 IKK
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.10 ATP
-
Homo sapiens