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Literature summary extracted from

  • Tanigawa, H.; Billheimer, J.T.; Tohyama, J.; Fuki, I.V.; Ng, D.S.; Rothblat, G.H.; Rader, D.J.
    Lecithin: cholesterol acyltransferase expression has minimal effects on macrophage reverse cholesterol transport in vivo (2009), Circulation, 120, 160-169.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.43 LCAT overexpression in transgenic mouse J774 macrophages Mus musculus
2.3.1.43 LCAT overexpression in transgenic mouse J774 macrophages Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.43 additional information LCAT overexpression in transgenic wild-type and human-apolipoprotein A-I-transgenic mice does not promote macrophage reverse cholesterol transport, even in the setting of hepatic SR-BI overexpression or CETP expression, overview Homo sapiens
2.3.1.43 additional information overexpression of human LCAT in transgenic wild-type and human-apolipoprotein A-I-transgenic mice does not promote macrophage reverse cholesterol transport, even in the setting of hepatic SR-BI overexpression or CETP expression, overview. LCAT heterozygous and homozygous deficient mice mutants, phenotypes, detailed overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.43 extracellular
-
 Mus musculus
-
-
2.3.1.43 extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.43 phosphatidylcholine + cholesterol Mus musculus
-
 cholesteryl ester + lysophosphatidylcholine
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol Homo sapiens
-
 cholesteryl ester + lysophosphatidylcholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Homo sapiens
-
-
-
2.3.1.43 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.43 blood plasma
-
 Mus musculus
-
2.3.1.43 blood plasma
-
 Homo sapiens
-
2.3.1.43 liver
-
 Mus musculus
-
2.3.1.43 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 phosphatidylcholine + cholesterol
-
 Mus musculus cholesteryl ester + lysophosphatidylcholine
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol
-
 Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol LCAT hydrolyzes the sn-2 acyl group of phosphatidylcholine and subsequently transfers and esterifies the fatty acid to the 3beta-hydroxy group of free cholesterol Mus musculus cholesteryl ester + lysophosphatidylcholine
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol LCAT hydrolyzes the sn-2 acyl group of phosphatidylcholine and subsequently transfers and esterifies the fatty acid to the 3beta-hydroxy group of free cholesterol Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.43 LCAT
-
 Mus musculus
2.3.1.43 LCAT
-
 Homo sapiens
2.3.1.43 lecithin: cholesterol acyltransferase
-
 Mus musculus
2.3.1.43 lecithin: cholesterol acyltransferase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.43 37
-
 assay at Mus musculus
2.3.1.43 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.43 7.4
-
 assay at Mus musculus
2.3.1.43 7.4
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.43 physiological function LCAT is a key enzyme in the metabolism of high-density lipoprotein, HDL Mus musculus
2.3.1.43 physiological function LCAT is a key enzyme in the metabolism of high-density lipoprotein, HDL. It is responsible for the synthesis of cholesteryl esters in human plasma. In addition to its role in HDL metabolism, LCAT has been proposed to have a critical and central role in reverse cholesterol transport, RCT, the process by which excess peripheral cholesterol is effluxed to HDL-based acceptors and returned to the liver for biliary excretion Homo sapiens