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Literature summary extracted from

  • Gundewar, S.; Calvert, J.W.; Jha, S.; Toedt-Pingel, I.; Ji, S.Y.; Nunez, D.; Ramachandran, A.; Anaya-Cisneros, M.; Tian, R.; Lefer, D.J.
    Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure (2009), Circ. Res., 104, 403-411.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.31 metformin improves cardiac structure and function, which is associated with increases in AMPK and endothelial nitric oxide synthase phosphorylation, as well as increased peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha expression in cardiac myocytes. Cardioprotective effects of metformin are ablated in mice lacking functional AMPK or nitric oxide synthase Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.31 cardiac-specific transgenic mice overexpressing a dominant-negative AMPKalpha2 subunit Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.31 Mus musculus
-
 C57BL/6J mice
-
2.7.11.31 Mus musculus C57/BL6J
-
 C57BL/6J mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.31 cardiac myocyte
-
 Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
2.7.11.31 AMP-activated protein kinase
-
 Mus musculus
2.7.11.31 AMPK
-
 Mus musculus