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Literature summary extracted from
- GSK-3beta, a therapeutic target for cardiomyocyte protection (2009), Circ. J., 73, 1184-1192.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.11.26 | lithium chloride | - |
Rattus norvegicus |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.7.11.26 | Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 2.7.11.26 | phosphoprotein | phosphorylation of GSK-3beta at Ser9 reduces activity of this kinase | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.7.11.26 | cardiomyocyte | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.11.26 | ATP + p53 | - |
Rattus norvegicus | ADP + phosphorylated p53 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.7.11.26 | glycogen synthase kinase-3beta | - |
Rattus norvegicus |
| 2.7.11.26 | GSK-3beta | - |
Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.11.26 | ATP | - |
Rattus norvegicus | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 2.7.11.26 | physiological function | GSK-3beta is a multifunctional Ser/Thr kinase that plays important roles in necrosis and apoptosis of cardiomyocytes | Rattus norvegicus |
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Release 2023.1 (January 2023)
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