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Literature summary extracted from

  • Singh, N.; Duenas-Gonzalez, A.; Lyko, F.; Medina-Franco, J.L.
    Molecular modeling and molecular dynamics studies of hydralazine with human DNA methyltransferase 1 (2009), ChemMedChem, 4, 792-799.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.37 drug development Dnmt inhibition is a promising strategy for the treatment of various developmental and proliferative diseases, particularly cancers Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.37 2'-dC binding modelling, overview Homo sapiens
2.1.1.37 2'-deoxy-5-aza-cytidine binding modelling, overview Homo sapiens
2.1.1.37 5-azacytidine binding modelling, overview Homo sapiens
2.1.1.37 decitabine binding modelling, overview Homo sapiens
2.1.1.37 hydralazine binding modelling, overview Homo sapiens
2.1.1.37 additional information inhibitor screening by molecular docking and molecular dynamics simulations Homo sapiens
2.1.1.37 procainamide binding modelling, overview Homo sapiens
2.1.1.37 procaine binding modelling, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.37 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.37 DNA + S-adenosyl-L-methionine Homo sapiens
-
 DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.37 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.1.37 S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine catalytic reaction mechanism of Dnmt1, overview Homo sapiens
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.37 DNA + S-adenosyl-L-methionine
-
 Homo sapiens DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?
2.1.1.37 additional information homology docking and molecular dynamics, overview Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.37 More homology model for DNMT1 based on the template structures of the available comparable protein crystal structures, molecular dynamics, overview Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.1.1.37 DNA methyltransferase 1
-
 Homo sapiens
2.1.1.37 Dnmt1
-
 Homo sapiens
2.1.1.37 More the enzyme belongs to the DNA methyltransferases, Dnmt, family of enzymes that methylates DNA at the C5 position of cytosine residues Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.37 S-adenosyl-L-methionine
-
 Homo sapiens