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Literature summary extracted from

  • Guan, W.; Cai, L.; Fang, J.; Wu, B.; George Wang, P.
    Enzymatic synthesis of UDP-GlcNAc/UDP-GalNAc analogs using N-acetylglucosamine 1-phosphate uridyltransferase (GlmU) (2009), Chem. Commun. (Camb. ), 2009, 6976-6978.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.23 Escherichia coli
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-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.23 additional information enzyme shows relaxed tolerance for modifications at N-acyl, C-3, C-4, and C-6 positions, with a preference for small substituent groups. The yields are low to moderate (10-65%) and some sugar-1-Ps fail to generate the corresponding UDP-sugars due to the steric problem Escherichia coli ?
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 ?
2.7.7.23 N-acetyl-4-deoxy-alpha-D-glucosamine 1-phosphate + UTP
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 Escherichia coli UDP-N-acetyl-4-deoxy-alpha-D-glucosamine + diphosphate yield: 59% ?
2.7.7.23 N-acetyl-6-deoxy-6-azido-alpha-D-glucosamine 1-phosphate + UTP
-
 Escherichia coli UDP-N-acetyl-6-deoxy-6-azido-alpha-D-glucosamine + diphosphate yield: 20% ?
2.7.7.23 N-acetyl-6-deoxy-alpha-D-galactosamine 1-phosphate + UTP
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 Escherichia coli UDP-N-acetyl-6-deoxy-alpha-D-galactosamine + diphosphate yield: 55% ?
2.7.7.23 N-acetyl-6-deoxy-alpha-D-glucosamine 1-phosphate + UTP
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 Escherichia coli UDP-N-acetyl-6-deoxy-alpha-D-glucosamine + diphosphate yield: 50% ?
2.7.7.23 N-acetyl-alpha-D-allopyranosylamine 1-phosphate + UTP
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 Escherichia coli UDP-N-acetyl-alpha-D-allopyranosylamine + diphosphate yield: 20% ?
2.7.7.23 N-acetyl-alpha-D-galactosamine 1-phosphate + UTP
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 Escherichia coli UDP-N-acetyl-alpha-D-galactosamine + diphosphate yield: 65% ?
2.7.7.23 N-acetyl-alpha-D-glucosamine 1-phosphate + UTP
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 Escherichia coli UDP-N-acetyl-alpha-D-glucosamine + diphosphate yield: 40% ?
2.7.7.23 N-azidoacetyl-alpha-D-glucosamine 1-phosphate + UTP
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 Escherichia coli UDP-N-azidoacetyl-alpha-D-glucosamine + diphosphate yield: 44% ?
2.7.7.23 N-butanoyl-alpha-D-glucosamine 1-phosphate + UTP
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 Escherichia coli UDP-N-butanoyl-alpha-D-glucosamine + diphosphate yield: 27% ?
2.7.7.23 N-propanoyl-alpha-D-galactosamine 1-phosphate + UTP
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 Escherichia coli UDP-N-propanoyl-alpha-D-galactosamine + diphosphate yield: 10% ?
2.7.7.23 N-propanoyl-alpha-D-glucosamine 1-phosphate + UTP
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 Escherichia coli UDP-N-propanoyl-alpha-D-glucosamine + diphosphate yield: 57% ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.23 GlmU
-
 Escherichia coli
2.7.7.23 N-acetylglucosamine 1-phosphate uridyltransferase
-
 Escherichia coli