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Literature summary extracted from

  • Vrsalovic Presecki, A.; Zelic, B.; Vasic-Racki, D.
    Modelling of continuous L-malic acid production by porcine heart fumarase and fumarase in yeast cells (2009), Chem. Biochem. Eng. Q., 23, 519-525.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.2.1.2 additional information activity of permeabilized cells in hydration of fumaric acid is significantly higher than that of the non-permeabilized ones Saccharomyces sp.
4.2.1.2 additional information activity of permeabilized cells in hydration of fumaric acid is significantly higher than that of the non-permeabilized ones Saccharomyces bayanus

Application

EC Number Application Comment Organism
4.2.1.2 industry use of purified enzyme in L-malic acid production is uneconomical because whole cells are cheaper. Use of one mg of purified fumarase in continuous production of L-malic acids, corresponds to the use of enzyme in 68 g (wet weight) cells of Saccharomyces bayanus or in 120 g (wet weight) cells of baker's yeast Sus scrofa
4.2.1.2 industry use of purified enzyme in L-malic acid production is uneconomical because whole cells are cheaper. Use of one mg of purified fumarase in continuous production of L-malic acids, corresponds to the use of enzyme in 68 g (wet weight) cells of Saccharomyces bayanus or in 120 g (wet weight) cells of baker's yeast Saccharomyces sp.
4.2.1.2 industry use of purified enzyme in L-malic acid production is uneconomical because whole cells are cheaper. Use of one mg of purified fumarase in continuous production of L-malic acids, corresponds to the use of enzyme in 68 g (wet weight) cells of Saccharomyces bayanus or in 120 g (wet weight) cells of baker's yeast Saccharomyces bayanus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.2 additional information during continuous L-malic acid production, enzyme inactivation, which is not complete Saccharomyces bayanus
4.2.1.2 additional information during continuous L-malic acid production, enzyme inactivation, which is not complete Saccharomyces sp.

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.2 cytosol
-
 Saccharomyces bayanus 5829
-
4.2.1.2 mitochondrion
-
 Saccharomyces bayanus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.2 Saccharomyces bayanus
-
-
-
4.2.1.2 Saccharomyces sp.
-
-
-
4.2.1.2 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.2
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.2 heart
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.2 fumarate + H2O
-
 Sus scrofa L-malate
-
 ?
4.2.1.2 fumarate + H2O
-
 Saccharomyces sp. L-malate
-
 ?
4.2.1.2 fumarate + H2O
-
 Saccharomyces bayanus L-malate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.2 fumarase
-
 Sus scrofa
4.2.1.2 fumarase
-
 Saccharomyces sp.
4.2.1.2 fumarase
-
 Saccharomyces bayanus

General Information

EC Number General Information Comment Organism
4.2.1.2 physiological function fumarase in permeabilized non-growing cells used as biocatalysts for continuous production of L-malic acid Saccharomyces sp.
4.2.1.2 physiological function fumarase in permeabilized non-growing cells used as biocatalysts for continuous production of L-malic acid Saccharomyces bayanus
4.2.1.2 physiological function purified fumarase used as biocatalysts for continuous production of L-malic acid Sus scrofa