Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sologub, M.; Litonin, D.; Anikin, M.; Mustaev, A.; Temiakov, D.
    TFB2 is a transient component of the catalytic site of the human mitochondrial RNA polymerase (2009), Cell, 139, 934-944.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.6 TFB2 the essential initiation factor forms a network of interactions with DNA near the transcription start site and facilitates promoter melting but may not be essential for promoter recognition, TFB2 bridges upstream and downstream promoter contacts of the initiation complex, mapping of TFB2-DNA interactions at the transcription start site, overview Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.6 expression of the N-terminally His6-tagged intein fusion mitoRNAP protein Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.6 G711K/N926S/N1103S/N1117S site-directed mutagenesis, the mutant mitoRNAP that lacks four natural hydroxylamine cleavage sites Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.6 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.6 additional information Homo sapiens molecular mechanisms of transcription regulation in mitochondria, molecular organization of the human mitochondrial transcription initiation complex, overview ?
-
 ?
2.7.7.6 nucleoside triphosphate + RNAn Homo sapiens
-
 diphosphate + RNAn+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.6 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.6 additional information molecular mechanisms of transcription regulation in mitochondria, molecular organization of the human mitochondrial transcription initiation complex, overview Homo sapiens ?
-
 ?
2.7.7.6 nucleoside triphosphate + RNAn
-
 Homo sapiens diphosphate + RNAn+1
-
 ?
2.7.7.6 nucleoside triphosphate + RNAn template is DNA Homo sapiens diphosphate + RNAn+1
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.6 monomer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.7.6 mitoRNAP
-
 Homo sapiens
2.7.7.6 More the enzyme belongs to the single-subunit, T7-like mitochondrial RNAP family Homo sapiens
2.7.7.6 RNA polymerase
-
 Homo sapiens
2.7.7.6 RNAP
-
 Homo sapiens
2.7.7.6 T7 RNAP
-
 Homo sapiens
2.7.7.6 T7-like RNA polymerase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.7.6 35
-
 assay at Homo sapiens