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Literature summary extracted from

  • Kaitaniemi, S.; Elovaara, H.; Groen, K.; Kidron, H.; Liukkonen, J.; Salminen, T.; Salmi, M.; Jalkanen, S.; Elima, K.
    The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase (2009), Cell. Mol. Life Sci., 66, 2743-2757.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.21 AOC2, cDNA library screening, DNA and amino acid sequence determination and analysis, transient expression of wild-type enzyme in HEK293, HEK293-EBNA or CHO cells Homo sapiens
1.4.3.21 AOC3, cDNA library screening, transient expression of wild-type and mutant enzymes in HEK293, HEK293-EBNA or CHO cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.4.3.21 M211V/Y394N/L469G AOC3 mutant Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.21 2-Phenylethylamine substrate inhibition Homo sapiens
1.4.3.21 benzylamine substrate inhibition Homo sapiens
1.4.3.21 hydroxylamine
-
 Homo sapiens
1.4.3.21 Semicarbazide
-
 Homo sapiens
1.4.3.21 tryptamine substrate inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.21 additional information
-
 additional information comparison of steady-state kinetics of enzyme expressed in CHO and HEK-293 EBNA cells, overview Homo sapiens
1.4.3.21 0.056
-
 tyramine recombinant enzyme expressed in CHO cells Homo sapiens
1.4.3.21 0.077
-
 2-Phenylethylamine recombinant enzyme expressed in CHO cells Homo sapiens
1.4.3.21 0.167
-
 benzylamine recombinant enzyme expressed in CHO cells Homo sapiens
1.4.3.21 0.178
-
 tyramine recombinant enzyme expressed in CHO cells Homo sapiens
1.4.3.21 0.67
-
 methylamine recombinant enzyme expressed in CHO cells Homo sapiens
1.4.3.21 1.7
-
 methylamine recombinant enzyme expressed in CHO cells Homo sapiens
1.4.3.21 1.94
-
 2-Phenylethylamine recombinant enzyme expressed in CHO cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.21 cell surface
-
 Homo sapiens 9986
-
1.4.3.21 membrane
-
 Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.4.3.21 Co2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.21 2-phenylethylamine + H2O + O2 Homo sapiens
-
 beta-phenylethanal + NH3 + H2O2
-
 ?
1.4.3.21 benzylamine + H2O + O2 Homo sapiens
-
 benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 benzylamine + H2O + O2 Homo sapiens low activity benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 methylamine + H2O + O2 Homo sapiens
-
 formaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 additional information Homo sapiens semicarbazide-sensitive amine oxidases constitute a group of copper-dependent enzymes, which oxidatively deaminate primary endo- and exogenous amines ?
-
 ?
1.4.3.21 tryptamine + H2O + O2 Homo sapiens
-
 (1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 tyramine + H2O + O2 Homo sapiens
-
 4-hydroxyphenylethanal + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.21 Homo sapiens O75106 AOC2
-
1.4.3.21 Homo sapiens Q16853 AOC3
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.21 brain
-
 Homo sapiens
-
1.4.3.21 cartilage
-
 Homo sapiens
-
1.4.3.21 eye
-
 Homo sapiens
-
1.4.3.21 heart
-
 Homo sapiens
-
1.4.3.21 kidney
-
 Homo sapiens
-
1.4.3.21 liver
-
 Homo sapiens
-
1.4.3.21 lung
-
 Homo sapiens
-
1.4.3.21 additional information tissue expression pattern of AOC2, overview Homo sapiens
-
1.4.3.21 ovary
-
 Homo sapiens
-
1.4.3.21 pancreas
-
 Homo sapiens
-
1.4.3.21 prostate gland
-
 Homo sapiens
-
1.4.3.21 retina
-
 Homo sapiens
-
1.4.3.21 skin
-
 Homo sapiens
-
1.4.3.21 testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.21 2-phenylethylamine + H2O + O2
-
 Homo sapiens beta-phenylethanal + NH3 + H2O2
-
 ?
1.4.3.21 benzylamine + H2O + O2
-
 Homo sapiens benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 benzylamine + H2O + O2 low activity Homo sapiens benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 methylamine + H2O + O2
-
 Homo sapiens formaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 methylamine + H2O + O2
-
 Homo sapiens formaldehyde + NH3 + H2O2
-
 r
1.4.3.21 additional information semicarbazide-sensitive amine oxidases constitute a group of copper-dependent enzymes, which oxidatively deaminate primary endo- and exogenous amines Homo sapiens ?
-
 ?
1.4.3.21 additional information AOC2 is an enzymatically active cell surface SSAO with distinct substrate specificity, the preferred in vitro substrates of AOC2 are 2-phenylethylamine, tryptamine and p-tyramine, cf. EC 1.4.3.4, instead of methylamine and benzylamine, the favored substrates of AOC3. Substrate docking, molecular modeling and comparison of AOC2 and AOC3, overview. No activity of AOC2 with methylamine, polyamine spermidine, or histamine Homo sapiens ?
-
 ?
1.4.3.21 additional information substrate docking, molecular modeling and comparison of AOC2 and AOC3, overview. No activity of AOC3 with polyamine spermidine or histamine Homo sapiens ?
-
 ?
1.4.3.21 tryptamine + H2O + O2
-
 Homo sapiens (1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 tryptamine + H2O + O2 high activity Homo sapiens (1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.21 tyramine + H2O + O2
-
 Homo sapiens 4-hydroxyphenylethanal + NH3 + H2O2
-
 ?
1.4.3.21 tyramine + H2O + O2 high activity Homo sapiens 4-hydroxyphenylethanal + NH3 + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.4.3.21 More AOC2 structure homology modelling, comparison with AOC3 Homo sapiens
1.4.3.21 More AOC3 structure homology modelling, comparison with AOC2 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.4.3.21 amine oxidase, copper containing
-
 Homo sapiens
1.4.3.21 AOC2
-
 Homo sapiens
1.4.3.21 AOC3
-
 Homo sapiens
1.4.3.21 RAO
-
 Homo sapiens
1.4.3.21 semicarbazide-sensitive amine oxidase
-
 Homo sapiens
1.4.3.21 SSAO
-
 Homo sapiens
1.4.3.21 VAP-1
-
 Homo sapiens
1.4.3.21 vascular adhesion protein-1
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.21 0.032
-
 tryptamine recombinant enzyme expressed in CHO cells Homo sapiens
1.4.3.21 0.08
-
 2-Phenylethylamine recombinant enzyme expressed in CHO cells Homo sapiens
1.4.3.21 0.089
-
 benzylamine recombinant enzyme expressed in CHO cells Homo sapiens