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Literature summary extracted from

  • Piao, Y.S.; Du, Y.C.; Oshima, H.; Jin, J.C.; Nomura, M.; Yoshimoto, T.; Oshima, M.
    Platelet-type 12-lipoxygenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency (2008), Carcinogenesis, 29, 440-447.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.13.11.31 drug development p12-LOX pathway may be an effective target of chemoprevention for skin carcinogenesis Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.31 baicalein p12-LOX specific inhibitor, suppresses proliferation of JB6 P+ cells when cells are seeded at a low density in a culture plate by 81% Mus musculus
1.13.11.31 siRNA inhibition of p12-LOX in JB6 P+ cells by siRNA transfection, causes a significant suppression of 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation by 61% compared with that in control cells Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.31 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.31 blood platelet
-
 Mus musculus
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1.13.11.31 additional information expression of p12-LOX is significantly higher in JB6P+ cells than in JB6P- cells that are resistant to transformation Mus musculus
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Synonyms

EC Number Synonyms Comment Organism
1.13.11.31 p12-LOX
-
 Mus musculus
1.13.11.31 platelet-type 12-lipoxygenase
-
 Mus musculus

Expression

EC Number Organism Comment Expression
1.13.11.31 Mus musculus tumor necrosis factor-alpha induces p12-LOX in the early stage of tumorigenesis, induces p12-LOX expression both in JB6P+ and JB6P- cells up

General Information

EC Number General Information Comment Organism
1.13.11.31 physiological function p12-LOX plays an important role in tumor development, is required for tumor promotion of epidermal cells. The enzyme is involved in activation of NF-kappaB in the tumor necrosis factor-alpha-stimulated JB6 P+ cells Mus musculus