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Literature summary extracted from

  • Cimen, I.; Tuncay, S.; Banerjee, S.
    15-Lipoxygenase-1 expression suppresses the invasive properties of colorectal carcinoma cell lines HCT-116 and HT-29 (2009), Cancer Sci., 100, 2283-2291.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.13.11.12 medicine 15-LO-1 expression in colorectal carcinoma may contribute to the inhibition of metastatic capacity in vitro and can be exploited for therapeutic purposes Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.12 into a pcDNA3.1 vector and introduced into HCT-116 and HT-29 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.12 PD146176
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.12 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.12 linoleic acid + O2
-
 Homo sapiens 13(S)-hydroxyoctadecadienoic acid
-
 ?

General Information

EC Number General Information Comment Organism
1.13.11.12 physiological function expression of 15-LO-1 significantly decreases cell proliferation and increases apoptosis. Reduces adhesion to fibronectin, anchorage-independent growth on soft agar, cellular motility and ability to heal a scratch wound, and migratory and invasive capacity across Matrigel. 15-LO-1 expression reduces the expression of metastasis associated protein-1, a part of the nucleosome remodeling and histone deacetylase silencing complex Homo sapiens