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Literature summary extracted from

  • Fan, G.; Fan, Y.; Gupta, N.; Matsuura, I.; Liu, F.; Zhou, X.Z.; Lu, K.P.; Gelinas, C.
    Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB family (2009), Cancer Res., 69, 4589-4597.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
5.2.1.8 pharmacology Pin1 is a potential therapeutic target in Rel/NF-kappaB-dependent leukemia/lymphomas Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
5.2.1.8 additional information a WW domain mutant of Pin1 can no longer interact with NF-kappaB Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.2.1.8 juglone Pin1 inhibition leads to relocalization of endogenous c-Rel to the cytoplasm coincident with lymphoma cell death and/or growth inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.2.1.8 additional information Homo sapiens Pin1 interacts with NF-kappaB via its WW domain ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.2.1.8 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.2.1.8 B-cell lymphoma cell
-
 Homo sapiens
-
5.2.1.8 carcinoma cell the enzyme is upregulated in cancer cells Homo sapiens
-
5.2.1.8 KM-H2 cell a Hodkin's lymphoma cell line Homo sapiens
-
5.2.1.8 lymphocyte primary Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.2.1.8 additional information Pin1 interacts with NF-kappaB via its WW domain Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.2.1.8 peptidyl-prolyl isomerase
-
 Homo sapiens
5.2.1.8 Pin1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
5.2.1.8 Homo sapiens the enzyme is upregulated in cancer cells up

General Information

EC Number General Information Comment Organism
5.2.1.8 physiological function Pin1 markedly enhances transformation in primary lymphocytes by the c-Rel protein and by viral Rel/NF-kappaB oncoprotein v-Rel, it enhances the nuclear translocation of the Rel proteins, overview Homo sapiens