BRENDA - Enzyme Database show

The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase

Costantino, C.L.; Witkiewicz, A.K.; Kuwano, Y.; Cozzitorto, J.A.; Kennedy, E.P.; Dasgupta, A.; Keen, J.C.; Yeo, C.J.; Gorospe, M.; Brody, J.R.; Cancer Res. 69, 4567-4572 (2009)

Data extracted from this reference:

Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.74
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
pancreatic cancer cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
703020
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + gemcitabine
-
703020
Homo sapiens
ADP + gemcitabine 5'-phosphate
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
pancreatic cancer cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
703020
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + gemcitabine
-
703020
Homo sapiens
ADP + gemcitabine 5'-phosphate
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
2.7.1.74
Homo sapiens
RNA-binding protein HuR silencing reduces dCK protein expression in pancreatic cancer cells
down
2.7.1.74
Homo sapiens
RNA-binding protein HuR overexpression elevates dCK protein expression in pancreatic cancer cells
up
Expression (protein specific)
EC Number
Organism
Commentary
Expression
2.7.1.74
Homo sapiens
RNA-binding protein HuR silencing reduces dCK protein expression in pancreatic cancer cells
down
2.7.1.74
Homo sapiens
RNA-binding protein HuR overexpression elevates dCK protein expression in pancreatic cancer cells
up