BRENDA - Enzyme Database

p19(ras) Represses proliferation of non-small cell lung cancer possibly through interaction with neuron-specific enolase (NSE)

Jang, S.M.; Kim, J.W.; Kim, C.H.; Kim, D.; Rhee, S.; Choi, K.H.; Cancer Lett. 289, 91-98 (2010)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
4.2.1.11
expressed in Escherichia coli BL21 cells
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.11
p19ras
when full-length p19ras and C-terminal region are bound to NSE, it inhibits the enzymatic activity of NSE, p19ras interacts with enolase alpha and represses its enzymatic activity in vitro
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.2.1.11
Homo sapiens
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
4.2.1.11
glutathione-Sepharose 4B bead chromatography, gel filtration
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.11
HEK-293 cell
-
Homo sapiens
-
4.2.1.11
NCI-H1299 cell
-
Homo sapiens
-
4.2.1.11
neuron
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.11
2-phospho-D-glycerate
-
703010
Homo sapiens
phosphoenolpyruvate + H2O
-
-
-
r
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
4.2.1.11
expressed in Escherichia coli BL21 cells
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.11
p19ras
when full-length p19ras and C-terminal region are bound to NSE, it inhibits the enzymatic activity of NSE, p19ras interacts with enolase alpha and represses its enzymatic activity in vitro
Homo sapiens
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
4.2.1.11
glutathione-Sepharose 4B bead chromatography, gel filtration
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.11
HEK-293 cell
-
Homo sapiens
-
4.2.1.11
NCI-H1299 cell
-
Homo sapiens
-
4.2.1.11
neuron
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.11
2-phospho-D-glycerate
-
703010
Homo sapiens
phosphoenolpyruvate + H2O
-
-
-
r