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Literature summary extracted from

  • Izbicka, E.; Diaz, A.; Streeper, R.; Wick, M.; Campos, D.; Steffen, R.; Saunders, M.
    Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers (2009), Cancer Chemother. Pharmacol., 64, 993-999.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.3 methotrexate
-
 Homo sapiens
1.5.1.3 pemetrexed
-
 Homo sapiens
1.5.1.3 pralatrexate
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.3 Homo sapiens
-
-
-
6.3.2.17 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.3 NCI-H460 cell
-
 Homo sapiens
-
6.3.2.17 NCI-H460 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.3 7,8-dihydrofolate + NADPH + H+
-
 Homo sapiens 5,6,7,8-tetrahydrofolate + NADP+
-
 ?
6.3.2.17 L-glutamate + ATP + aminopterin assay at 37°C Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.3 DHFR
-
 Homo sapiens
1.5.1.3 dihydrofolate reductase
-
 Homo sapiens
6.3.2.17 folypolyglutamate synthetase
-
 Homo sapiens
6.3.2.17 FPGS
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.3.2.17 37
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.5.1.3 additional information
-
 pemetrexed value above 0.0002 mM Homo sapiens
1.5.1.3 0.000026
-
 methotrexate
-
 Homo sapiens
1.5.1.3 0.000045
-
 pralatrexate
-
 Homo sapiens