Literature summary extracted from

Tu, S.H.; Chang, C.C.; Chen, C.S.; Tam, K.W.; Wang, Y.J.; Lee, C.H.; Lin, H.W.; Cheng, T.C.; Huang, C.S.; Chu, J.S.; Shih, N.Y.; Chen, L.C.; Leu, S.J.; Ho, Y.S.; Wu, C.H.
Increased expression of enolase alpha in human breast cancer confers tamoxifen resistance in human breast cancer cells (2010), Breast Cancer Res. Treat., 121, 539-553.

Application

EC Number	Application	Comment	Organism
4.2.1.11	medicine	changes in tumor ENO-1 levels are related to clinical 4-hydroxytamoxifen therapeutic outcome, downregulation of ENO-1 can be utilized as a pharmacological approach for overcoming 4-hydroxytamoxifen resistance in breast cancer therapy	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.2.1.11	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
4.2.1.11	AU-565 cell	-	Homo sapiens	-
4.2.1.11	breast cancer cell	-	Homo sapiens	-
4.2.1.11	BT-483 cell	-	Homo sapiens	-
4.2.1.11	HBL-100 cell	-	Homo sapiens	-
4.2.1.11	MCF-10A cell	-	Homo sapiens	-
4.2.1.11	MCF-7 cell	-	Homo sapiens	-
4.2.1.11	MDA-MB-231 cell	-	Homo sapiens	-
4.2.1.11	MDA-MB-453 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.2.1.11	2-phospho-D-glycerate	-	Homo sapiens	phosphoenolpyruvate	-	r

Synonyms

EC Number	Synonyms	Comment	Organism
4.2.1.11	ENO-1	-	Homo sapiens
4.2.1.11	enolase-alpha	-	Homo sapiens

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Release 2023.1 (January 2023)