BRENDA - Enzyme Database

Increased expression of enolase alpha in human breast cancer confers tamoxifen resistance in human breast cancer cells

Tu, S.H.; Chang, C.C.; Chen, C.S.; Tam, K.W.; Wang, Y.J.; Lee, C.H.; Lin, H.W.; Cheng, T.C.; Huang, C.S.; Chu, J.S.; Shih, N.Y.; Chen, L.C.; Leu, S.J.; Ho, Y.S.; Wu, C.H.; Breast Cancer Res. Treat. 121, 539-553 (2010)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
4.2.1.11
medicine
changes in tumor ENO-1 levels are related to clinical 4-hydroxytamoxifen therapeutic outcome, downregulation of ENO-1 can be utilized as a pharmacological approach for overcoming 4-hydroxytamoxifen resistance in breast cancer therapy
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.2.1.11
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.11
AU-565 cell
-
Homo sapiens
-
4.2.1.11
breast cancer cell
-
Homo sapiens
-
4.2.1.11
BT-483 cell
-
Homo sapiens
-
4.2.1.11
HBL-100 cell
-
Homo sapiens
-
4.2.1.11
MCF-10A cell
-
Homo sapiens
-
4.2.1.11
MCF-7 cell
-
Homo sapiens
-
4.2.1.11
MDA-MB-231 cell
-
Homo sapiens
-
4.2.1.11
MDA-MB-453 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.11
2-phospho-D-glycerate
-
702980
Homo sapiens
phosphoenolpyruvate
-
-
-
r
Application (protein specific)
EC Number
Application
Commentary
Organism
4.2.1.11
medicine
changes in tumor ENO-1 levels are related to clinical 4-hydroxytamoxifen therapeutic outcome, downregulation of ENO-1 can be utilized as a pharmacological approach for overcoming 4-hydroxytamoxifen resistance in breast cancer therapy
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.11
AU-565 cell
-
Homo sapiens
-
4.2.1.11
breast cancer cell
-
Homo sapiens
-
4.2.1.11
BT-483 cell
-
Homo sapiens
-
4.2.1.11
HBL-100 cell
-
Homo sapiens
-
4.2.1.11
MCF-10A cell
-
Homo sapiens
-
4.2.1.11
MCF-7 cell
-
Homo sapiens
-
4.2.1.11
MDA-MB-231 cell
-
Homo sapiens
-
4.2.1.11
MDA-MB-453 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.11
2-phospho-D-glycerate
-
702980
Homo sapiens
phosphoenolpyruvate
-
-
-
r