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Literature summary extracted from

  • Cheng, S.Y.; Serova, L.I.; Glazkova, D.; Sabban, E.L.
    Regulation of rat dopamine beta-hydroxylase gene transcription by early growth response gene 1 (Egr1) (2008), Brain Res., 1193, 1-11.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.17.1 cAMP non-hydrolysable cAMP analog stimulates DBH promoter activity Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.17.1 C12 cells transfected with expression vector for full length or truncated inactive Egr1 and DBH promoter-driven luciferase constructs p5'DBH/Luc (-1625/+21), p5'DBH/Luc (-247/+21) and p5'DBH/Luc (-200/+21) Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Rattus norvegicus
-
-
-

Synonyms

EC Number Synonyms Comment Organism
1.14.17.1 DBH
-
 Rattus norvegicus
1.14.17.1 dopamine beta-hydroxylase
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.14.17.1 Rattus norvegicus Egr1 reduces DBH promoter activity, reduction occurrs as early as 4 h and reaches maximal inhibition 16-40 h after transfection. Egr1 also reduces the expression of endogenous DBH mRNA and the induction of DBH promoter activity by cAMP. The first 247, but not 200, nucleotides of DBH promoter are sufficient for suppression down

General Information

EC Number General Information Comment Organism
1.14.17.1 physiological function DBH promoter contains at least one functional Egr1 motif, Egr1 may play a role in the physiological regulation of transcription of the DBH gene Rattus norvegicus