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Literature summary extracted from

  • Ikeda-Matsuo, Y.; Hirayama, Y.; Ota, A.; Uematsu, S.; Akira, S.; Sasaki, Y.
    Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity (2010), Br. J. Pharmacol., 159, 1174-1186.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.3 MK-886 glutamate-induced PGE2 production is suppressed almost completely by MK-886 at a concentration of 0.003 mM or higher Mus musculus
5.3.99.3 MK-886 glutamate-induced PGE2 production is suppressed almost completely by MK-886 at a concentration of 0.003 mM or higher Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.3 microsome
-
 Mus musculus
-
-
5.3.99.3 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.3 Mus musculus
-
-
-
5.3.99.3 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.3 hippocampus
-
 Mus musculus
-
5.3.99.3 hippocampus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.3 Prostaglandin H2
-
 Mus musculus Prostaglandin E2
-
 ?
5.3.99.3 Prostaglandin H2
-
 Rattus norvegicus Prostaglandin E2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.3 microsomal prostaglandin E synthase-1
-
 Mus musculus
5.3.99.3 microsomal prostaglandin E synthase-1
-
 Rattus norvegicus
5.3.99.3 mPGES-1
-
 Mus musculus
5.3.99.3 mPGES-1
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.3.99.3 0.0024
-
-
 Mus musculus MK-886
5.3.99.3 0.0024
-
-
 Rattus norvegicus MK-886

Expression

EC Number Organism Comment Expression
5.3.99.3 Mus musculus 1 mM glutamate up-regulates the expression of mPGES-1 to about 3fold that in the controls up
5.3.99.3 Rattus norvegicus 1 mM glutamate up-regulates the expression of mPGES-1 to about 3fold that in the controls up

General Information

EC Number General Information Comment Organism
5.3.99.3 physiological function microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are co-induced by excess glutamate in ischaemic brain. mPGES-1 activity is required for cyclooxygenase-2 to cause neuronal damage in ischaemic injury Mus musculus
5.3.99.3 physiological function microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are co-induced by excess glutamate in ischaemic brain. mPGES-1 activity is required for cyclooxygenase-2 to cause neuronal damage in ischaemic injury Rattus norvegicus