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Literature summary extracted from

  • Li, N.; Wang, F.; Niu, S.; Cao, J.; Wu, K.; Li, Y.; Yin, N.; Zhang, X.; Zhu, W.; Yin, Y.
    Discovery of novel inhibitors of Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase (VicK) (2009), BMC Microbiol., 9, 129.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.13.3 expressed in Escherichia coli BL21(DE3) cells Streptococcus pneumoniae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.13.3 2-(3,4-dimethoxyphenyl)-N-[(5-phenylfuran-2-yl)methyl]ethanaminium
-
 Streptococcus pneumoniae
2.7.13.3 2-[[(4-amino-1,2,5-oxadiazol-3-yl)carbonyl]amino]-N-[4-(thiophen-2-ylmethoxy)benzyl]ethanaminium
-
 Streptococcus pneumoniae
2.7.13.3 2-[[(4-amino-1,2,5-oxadiazol-3-yl)carbonyl]amino]-N-[[5-(3-chloro-4-methoxyphenyl)furan-2-yl]methyl]ethanaminium
-
 Streptococcus pneumoniae
2.7.13.3 N,N'-bis(1H-benzimidazol-2-yl)biphenyl-4,4'-diamine
-
 Streptococcus pneumoniae
2.7.13.3 N-[[5-(2-fluorophenyl)furan-2-yl]methyl]-3-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]propan-1-aminium
-
 Streptococcus pneumoniae
2.7.13.3 N-[[5-(3-chloro-4-fluorophenyl)furan-2-yl]methyl]-3-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]propan-1-aminium
-
 Streptococcus pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
2.7.13.3 Streptococcus pneumoniae Q9S1J9
-
-
2.7.13.3 Streptococcus pneumoniae D39 / ATCC 7466 Q9S1J9
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.13.3
-
 Streptococcus pneumoniae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.13.3 ATP + VicR protein L-histidine
-
 Streptococcus pneumoniae ADP + VicR protein N-phospho-L-histidine
-
 ?
2.7.13.3 ATP + VicR protein L-histidine
-
 Streptococcus pneumoniae D39 / ATCC 7466 ADP + VicR protein N-phospho-L-histidine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.13.3 VicK
-
 Streptococcus pneumoniae

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.13.3 ATP
-
 Streptococcus pneumoniae