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Literature summary extracted from

  • Nykopp, T.; Rilla, K.; Sironen, R.; Tammi, M.; Tammi, R.; Hämäläinen, K.; Heikkinen, A.; Komulainen, M.; Kosma, V.; Anttila, M.
    Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: Inverse correlation between HYAL1 and hyaluronan content (2009), BMC Cancer, 9, 143.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.4.1.212 medicine in serous epithelial ovarian tumors, expression of HAS1 is low or absent. The levels of HAS2 and HAS3 mRNA are not consistently increased in the carcinomas, and are not significantly correlated with HAS protein or hyaluronan accumulation in individual samples Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.212 Homo sapiens O00219 isoform HAS3
-
2.4.1.212 Homo sapiens Q92819 isoform HAS2
-
3.2.1.35 Homo sapiens Q12794
-
-
3.2.1.35 Homo sapiens Q12891
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.212 ovarian serous carcinoma cell serous epithelial ovarian tumor Homo sapiens
-
2.4.1.212 ovary serous epithelial ovarian tumor Homo sapiens
-
2.4.1.212 ovary epithelium cell line serous epithelial ovarian tumor Homo sapiens
-
3.2.1.35 ovarian serous carcinoma cell
-
 Homo sapiens
-
3.2.1.35 ovary
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.35 hyaluronan + 2 H2O
-
 Homo sapiens N-acetyl-beta-D-glucosamine + D-glucuronate + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.212 Has3
-
 Homo sapiens
2.4.1.212 hyaluronan synthase 2
-
 Homo sapiens
3.2.1.35 HYAL1
-
 Homo sapiens
3.2.1.35 Hyal2
-
 Homo sapiens
3.2.1.35 hyaluronidase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.2.1.35 Homo sapiens the median of isoform HYAL1 mRNA level is 69% lower in grade 3 serous ovarian cancers compared to normal ovaries down