Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Li, X.; Hu, X.; Patel, B.; Zhou, Z.; Liang, S.; Ybarra, R.; Qiu, Y.; Felsenfeld, G.; Bungert, J.; Huang, S.
    H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation (2010), Blood, 115, 2028-2037.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.48 dimethyl-arginine 3-histone H4 dimethyl H4R3 provides a binding surface for PCAF and directly enhances histone H3 and H4 acetylation in vitro Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.48 additional information knockdown of PRMT1 by RNAi in erythroid progenitor cells prevents histone acetylation, enhancer and promoter interaction, and recruitment of transcription complexes to the active beta-globin promoter. Restoration of PRMT1 expression in PRMT1 knockout cells rescues erythroid differentiation and beta-globin transcription Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.48 nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H3 Mus musculus H4R3 methylation, catalyzed by PRMT1, facilitates beta-globin transcription by regulating histone acetyltransferase binding, and histone H3 and H4 acetylation, overview CoA + acetylhistone H3
-
 ?
2.3.1.48 acetyl-CoA + histone H4 Mus musculus H4R3 methylation, catalyzed by PRMT1, facilitates beta-globin transcription by regulating histone acetyltransferase binding, and histone H3 and H4 acetylation, overview CoA + acetylhistone H4
-
 ?
2.3.1.48 additional information Mus musculus PCAF is present in USF1/PRMT1 complexes ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Mus musculus
-
 PCAF and CBP
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 embryonic stem cell
-
 Mus musculus
-
2.3.1.48 erythroid cell
-
 Mus musculus
-
2.3.1.48 MEL cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H3 H4R3 methylation, catalyzed by PRMT1, facilitates beta-globin transcription by regulating histone acetyltransferase binding, and histone H3 and H4 acetylation, overview Mus musculus CoA + acetylhistone H3
-
 ?
2.3.1.48 acetyl-CoA + histone H3 acetylation of Lys9 and Lys14 by PCAF. PCAF binds to dimethyl-Arg3 at histone H4 tails, dimethyl H4R3 provides a binding surface for PCAF and directly enhances histone H3 and H4 acetylation in vitro Mus musculus CoA + acetylhistone H3
-
 ?
2.3.1.48 acetyl-CoA + histone H4 H4R3 methylation, catalyzed by PRMT1, facilitates beta-globin transcription by regulating histone acetyltransferase binding, and histone H3 and H4 acetylation, overview Mus musculus CoA + acetylhistone H4
-
 ?
2.3.1.48 acetyl-CoA + histone H4 PCAF binds to dimethyl-Arg3 at histone H4 tails, dimethyl H4R3 provides a binding surface for PCAF and directly enhances histone H3 and H4 acetylation in vitro Mus musculus CoA + acetylhistone H4
-
 ?
2.3.1.48 additional information PCAF is present in USF1/PRMT1 complexes Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 Cbp
-
 Mus musculus
2.3.1.48 PCAF
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.48 acetyl-CoA
-
 Mus musculus