EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.6.1.7 | KAT II complex with 2-oxoglutarate, hanging drop vapor diffusion method | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.7 | 3-hydroxykynurenine | less than 35% inhibition at 5 mM | Homo sapiens | |
2.6.1.7 | aminoadipate | less than 35% inhibition at 5 mM | Homo sapiens | |
2.6.1.7 | L-asparagine | less than 35% inhibition at 5 mM | Homo sapiens | |
2.6.1.7 | L-cysteine | less than 35% inhibition at 5 mM | Homo sapiens | |
2.6.1.7 | L-glutamate | less than 35% inhibition at 5 mM | Homo sapiens | |
2.6.1.7 | L-histidine | less than 35% inhibition at 5 mM | Homo sapiens | |
2.6.1.7 | L-lysine | less than 35% inhibition at 5 mM | Homo sapiens | |
2.6.1.7 | L-phenylalanine | less than 35% inhibition at 5 mM | Homo sapiens | |
2.6.1.7 | additional information | not inhibited by glyoxylate | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.6.1.7 | 1.2 | - |
2-oxoglutarate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 1.4 | - |
indo-3-pyruvate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 1.5 | - |
2-oxocaproate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 1.5 | - |
hydroxyphenylpyruvate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 1.8 | - |
phenylpyruvate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 2.4 | - |
2-oxo-4-methylthiobutyrate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 2.8 | - |
Mercaptopyruvate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 3.3 | - |
4-methyl-2-oxopentanoate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 3.4 | - |
2-oxovalerate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 4.7 | - |
L-kynurenine | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 9.7 | - |
pyruvate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 12.7 | - |
2-oxobutyrate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 12.9 | - |
3-methyl-2-oxobutanoate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 14.2 | - |
3-methyl-2-oxobutanoate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 16.8 | - |
oxaloacetate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 18 | - |
glyoxylate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 20.9 | - |
2-oxoadipate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.6.1.39 | cytoplasm | - |
Homo sapiens | 5737 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.6.1.7 | Homo sapiens | Q8N5Z0 | - |
- |
2.6.1.39 | Homo sapiens | Q8N5Z0 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.6.1.7 | DEAE-Sepharose column chromatography, hydroxyapatite column chromatography, and gel filtration | Homo sapiens |
EC Number | Storage Stability | Organism |
---|---|---|
2.6.1.7 | -80°C, isolated KAT II, no noticeable decrease in specific activity | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.7 | L-kynurenine + 2-oxo-4-methylthiobutyrate | - |
Homo sapiens | ? | - |
? | |
2.6.1.7 | L-kynurenine + 2-oxoadipate | - |
Homo sapiens | ? | - |
? | |
2.6.1.7 | L-kynurenine + 2-oxobutyrate | - |
Homo sapiens | kynurenic acid + 2-aminobutanoate + H2O | - |
? | |
2.6.1.7 | L-kynurenine + 2-oxocaproate | - |
Homo sapiens | ? | - |
? | |
2.6.1.7 | L-kynurenine + 2-oxoglutarate | - |
Homo sapiens | kynurenic acid + L-glutamate + H2O | - |
? | |
2.6.1.7 | L-kynurenine + 2-oxovalerate | - |
Homo sapiens | ? | - |
? | |
2.6.1.7 | L-kynurenine + 3-methyl-2-oxobutanoate | - |
Homo sapiens | ? | - |
? | |
2.6.1.7 | L-kynurenine + 3-methyl-2-oxopentanoate | - |
Homo sapiens | ? | - |
? | |
2.6.1.7 | L-kynurenine + 4-methyl-2-oxopentanoate | - |
Homo sapiens | ? | - |
? | |
2.6.1.7 | L-kynurenine + glyoxylate | glyoxylate shows a relatively low affinity for KAT II | Homo sapiens | 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine | - |
? | |
2.6.1.7 | L-kynurenine + hydroxyphenylpyruvate | - |
Homo sapiens | ? | - |
? | |
2.6.1.7 | L-kynurenine + indo-3-pyruvate | - |
Homo sapiens | ? | - |
? | |
2.6.1.7 | L-kynurenine + mercaptopyruvate | - |
Homo sapiens | ? | - |
? | |
2.6.1.7 | L-kynurenine + oxaloacetate | - |
Homo sapiens | ? | - |
? | |
2.6.1.7 | L-kynurenine + phenylpyruvate | - |
Homo sapiens | ? | - |
? | |
2.6.1.7 | L-kynurenine + pyruvate | - |
Homo sapiens | ? | - |
? | |
2.6.1.7 | additional information | 2-oxoglutarate, 2-oxocaproate, phenylpyruvate, and 2-oxo-4-methylthiobutyrate are highly efficient as amino-group acceptors for KAT II | Homo sapiens | ? | - |
? | |
2.6.1.39 | L-2-aminoadipate + 2-oxoglutarate | - |
Homo sapiens | 2-oxoadipate + L-glutamate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.6.1.7 | KAT II | - |
Homo sapiens |
2.6.1.7 | kynurenine aminotransferase II | - |
Homo sapiens |
2.6.1.39 | AadAT | - |
Homo sapiens |
2.6.1.39 | aminoadipate aminotransferase | - |
Homo sapiens |
2.6.1.39 | aminoadipate aminotransferase/kynurenine aminotransferase II | - |
Homo sapiens |
2.6.1.39 | KAT II/AADAT | bifunctional enzyme with kynurenine aminotransferase activity and aminoadipate aminotransferase function | Homo sapiens |
2.6.1.39 | kynurenine aminotransferase II | - |
Homo sapiens |
2.6.1.39 | More | KAT II is identical to AADAT (aminoadipate aminotransferase) | Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.6.1.7 | 50 | - |
- |
Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.6.1.7 | 0.065 | - |
oxaloacetate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 0.36 | - |
pyruvate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 0.39 | - |
hydroxyphenylpyruvate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 0.92 | - |
3-methyl-2-oxobutanoate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 0.92 | - |
3-methyl-2-oxopentanoate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 1.49 | - |
indo-3-pyruvate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 2.51 | - |
4-methyl-2-oxopentanoate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 2.66 | - |
2-oxovalerate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 3.49 | - |
2-oxobutyrate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 3.59 | - |
Mercaptopyruvate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 3.64 | - |
glyoxylate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 4.27 | - |
2-oxo-4-methylthiobutyrate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 4.73 | - |
phenylpyruvate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 4.83 | - |
2-oxocaproate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 4.84 | - |
2-oxoadipate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 7.67 | - |
2-oxoglutarate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 9.76 | - |
L-kynurenine | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
2.6.1.7 | 7 | 9 | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.7 | pyridoxal 5'-phosphate | - |
Homo sapiens |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.6.1.7 | 0.04 | - |
pyruvate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 0.065 | - |
3-methyl-2-oxopentanoate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 0.07 | - |
3-methyl-2-oxobutanoate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 0.09 | - |
oxaloacetate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 0.2 | - |
glyoxylate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 0.23 | - |
2-oxoadipate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 0.27 | - |
2-oxobutyrate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 0.27 | - |
hydroxyphenylpyruvate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 0.76 | - |
4-methyl-2-oxopentanoate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 0.78 | - |
2-oxovalerate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 1.08 | - |
indo-3-pyruvate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 1.23 | - |
Mercaptopyruvate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 1.75 | - |
2-oxo-4-methylthiobutyrate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 2.62 | - |
phenylpyruvate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 3.13 | - |
2-oxocaproate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 3.27 | - |
L-kynurenine | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens | |
2.6.1.7 | 6.24 | - |
2-oxoglutarate | in 100 mM potassium phosphate buffer (pH 7.4), at 37°C | Homo sapiens |