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Literature summary extracted from

  • Hyun, T.K.; Havlicek, L.; Strnad, M.; Roitsch, T.
    Trisubstituted purines are useful tools for developing potent plant mitogen-activated protein kinase inhibitors (2010), Biosci. Biotechnol. Biochem., 74, 553-557.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.24 additional information activation of MAPKs from photoautotrophic cultures of tomato by treatment with E-Fol, the elicitor preparation of the wilt-inducing fungus Fusarium oxysporum lycopersici Solanum peruvianum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.24 (2S)-2-([6-[(2-aminobenzyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino)butan-1-ol
-
 Solanum peruvianum
2.7.11.24 2,2'-[[6-(benzylamino)-9-(1-methylethyl)-9H-purin-2-yl]imino]diethanol
-
 Solanum peruvianum
2.7.11.24 2-(2-[[6-(benzylamino)-9-(1-methylethyl)-9H-purin-2-yl]amino]ethoxy)ethanol
-
 Solanum peruvianum
2.7.11.24 2-([6-[(3-methylbut-2-en-1-yl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino)ethanol
-
 Solanum peruvianum
2.7.11.24 2-([9-methyl-6-[(3-methylbut-2-en-1-yl)amino]-9H-purin-2-yl]amino)ethanol
-
 Solanum peruvianum
2.7.11.24 2-([[2-[[(1S)-1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl)phenol
-
 Solanum peruvianum
2.7.11.24 2-([[2-[[1-(hydroxymethyl)-2-methylbutyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl)phenol
-
 Solanum peruvianum
2.7.11.24 2-([[9-(1-methylethyl)-2-(4-prop-2-yn-1-ylpiperazin-1-yl)-9H-purin-6-yl]amino]methyl)phenol
-
 Solanum peruvianum
2.7.11.24 2-([[9-(1-methylethyl)-2-piperazin-1-yl-9H-purin-6-yl]amino]methyl)phenol
-
 Solanum peruvianum
2.7.11.24 2-([[9-(1-methylethyl)-2-propyl-9H-purin-6-yl]amino]methyl)phenol
-
 Solanum peruvianum
2.7.11.24 2-chloro-N-(cyclohexylmethyl)-9H-purin-6-amine
-
 Solanum peruvianum
2.7.11.24 2-[(6-amino-9H-purin-2-yl)amino]ethanol
-
 Solanum peruvianum
2.7.11.24 2-[6-(benzylamino)-2-[(2-hydroxyethyl)amino]-9H-purin-9-yl]ethanol
-
 Solanum peruvianum
2.7.11.24 2-[[6-(benzylamino)-9-(1-methylethyl)-9H-purin-2-yl]amino]ethanol
-
 Solanum peruvianum
2.7.11.24 2-[[6-(benzylamino)-9-(1-methylethyl)-9H-purin-2-yl]sulfanyl]ethanol
-
 Solanum peruvianum
2.7.11.24 3-([[2-(heptylamino)-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl)phenol
-
 Solanum peruvianum
2.7.11.24 3-([[2-[[1-(hydroxymethyl)-2-methylbutyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl)phenol
-
 Solanum peruvianum
2.7.11.24 3-([[2-[[1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl)phenol
-
 Solanum peruvianum
2.7.11.24 3-[([2-[(3-hydroxypropyl)amino]-9-(1-methylethyl)-9H-purin-6-yl]amino)methyl]phenol
-
 Solanum peruvianum
2.7.11.24 3-[[6-(benzylsulfanyl)-9-(1-methylethyl)-9H-purin-2-yl]amino]propan-1-ol
-
 Solanum peruvianum
2.7.11.24 4-([[2-(benzylamino)-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl)phenol
-
 Solanum peruvianum
2.7.11.24 6-(benzylsulfanyl)-2-chloro-9-(1-methylethyl)-9H-purine
-
 Solanum peruvianum
2.7.11.24 bohemine
-
 Solanum peruvianum
2.7.11.24 N-(2-aminobenzyl)-2-chloro-9-(1-methylethyl)-9H-purin-6-amine
-
 Solanum peruvianum
2.7.11.24 N-benzyl-9-(1-methylethyl)-2-(methylsulfanyl)-9H-purin-6-amine
-
 Solanum peruvianum
2.7.11.24 N-benzyl-9-(1-methylethyl)-9H-purin-6-amine
-
 Solanum peruvianum
2.7.11.24 N-benzyl-9-methyl-2-morpholin-4-yl-9H-purin-6-amine
-
 Solanum peruvianum
2.7.11.24 N-methyl-9-(1-methylethyl)-9H-purin-6-amine
-
 Solanum peruvianum
2.7.11.24 N6-(2-aminobenzyl)-N2-(4-aminocyclohexyl)-9-(1-methylethyl)-9H-purine-2,6-diamine
-
 Solanum peruvianum
2.7.11.24 N6-benzyl-9-(1-methylethyl)-9H-purine-2,6-diamine
-
 Solanum peruvianum
2.7.11.24 olomucine
-
 Solanum peruvianum
2.7.11.24 roscovitine
-
 Solanum peruvianum
2.7.11.24 staurosporine
-
 Solanum peruvianum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.24 ATP + a protein Solanum peruvianum
-
 ADP + a phosphoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.24 Solanum peruvianum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.24 elicitor-induced MAPK is purified from the protein extract of cells by anion-exchange chromatography Solanum peruvianum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.24 ATP + a protein
-
 Solanum peruvianum ADP + a phosphoprotein
-
 ?
2.7.11.24 ATP + myelin basic protein substrate in kinase assay Solanum peruvianum ADP + a phosphorylated myelin basic protein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.24 MAP kinase
-
 Solanum peruvianum
2.7.11.24 MAPK
-
 Solanum peruvianum
2.7.11.24 mitogen-activated kinase
-
 Solanum peruvianum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.24 22
-
 kinase assay at room temperature Solanum peruvianum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.24 7.5
-
 kinase assay Solanum peruvianum

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.24 ATP
-
 Solanum peruvianum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.24 additional information
-
 relative activity, 10% of control Solanum peruvianum staurosporine
2.7.11.24 additional information
-
 relative activity, 100% of control Solanum peruvianum 2-[6-(benzylamino)-2-[(2-hydroxyethyl)amino]-9H-purin-9-yl]ethanol
2.7.11.24 additional information
-
 relative activity, 115% of control Solanum peruvianum 3-[[6-(benzylsulfanyl)-9-(1-methylethyl)-9H-purin-2-yl]amino]propan-1-ol
2.7.11.24 additional information
-
 relative activity, 125% of control Solanum peruvianum 2-chloro-N-(cyclohexylmethyl)-9H-purin-6-amine
2.7.11.24 additional information
-
 relative activity, 127% of control Solanum peruvianum 4-([[2-(benzylamino)-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl)phenol
2.7.11.24 additional information
-
 relative activity, 135% of control Solanum peruvianum 6-(benzylsulfanyl)-2-chloro-9-(1-methylethyl)-9H-purine
2.7.11.24 additional information
-
 relative activity, 138% of control Solanum peruvianum 2-[(6-amino-9H-purin-2-yl)amino]ethanol
2.7.11.24 additional information
-
 relative activity, 20% of control Solanum peruvianum roscovitine
2.7.11.24 additional information
-
 relative activity, 23% of control Solanum peruvianum 2-([[2-[[(1S)-1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl)phenol
2.7.11.24 additional information
-
 relative activity, 24% of control Solanum peruvianum 2-[[6-(benzylamino)-9-(1-methylethyl)-9H-purin-2-yl]sulfanyl]ethanol
2.7.11.24 additional information
-
 relative activity, 37% of control Solanum peruvianum 2,2'-[[6-(benzylamino)-9-(1-methylethyl)-9H-purin-2-yl]imino]diethanol
2.7.11.24 additional information
-
 relative activity, 38% of control Solanum peruvianum 3-[([2-[(3-hydroxypropyl)amino]-9-(1-methylethyl)-9H-purin-6-yl]amino)methyl]phenol
2.7.11.24 additional information
-
 relative activity, 41% of control Solanum peruvianum N-benzyl-9-(1-methylethyl)-9H-purin-6-amine
2.7.11.24 additional information
-
 relative activity, 43% of control Solanum peruvianum 2-[[6-(benzylamino)-9-(1-methylethyl)-9H-purin-2-yl]amino]ethanol
2.7.11.24 additional information
-
 relative activity, 44% of control Solanum peruvianum 2-([9-methyl-6-[(3-methylbut-2-en-1-yl)amino]-9H-purin-2-yl]amino)ethanol
2.7.11.24 additional information
-
 relative activity, 44% of control Solanum peruvianum 3-([[2-[[1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl)phenol
2.7.11.24 additional information
-
 relative activity, 44% of control Solanum peruvianum bohemine
2.7.11.24 additional information
-
 relative activity, 46% of control Solanum peruvianum N6-(2-aminobenzyl)-N2-(4-aminocyclohexyl)-9-(1-methylethyl)-9H-purine-2,6-diamine
2.7.11.24 additional information
-
 relative activity, 48% of control Solanum peruvianum N6-benzyl-9-(1-methylethyl)-9H-purine-2,6-diamine
2.7.11.24 additional information
-
 relative activity, 50% of control Solanum peruvianum 2-([[2-[[1-(hydroxymethyl)-2-methylbutyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl)phenol
2.7.11.24 additional information
-
 relative activity, 50% of control Solanum peruvianum N-(2-aminobenzyl)-2-chloro-9-(1-methylethyl)-9H-purin-6-amine
2.7.11.24 additional information
-
 relative activity, 52% of control Solanum peruvianum 2-([[9-(1-methylethyl)-2-piperazin-1-yl-9H-purin-6-yl]amino]methyl)phenol
2.7.11.24 additional information
-
 relative activity, 54% of control Solanum peruvianum 2-([[9-(1-methylethyl)-2-propyl-9H-purin-6-yl]amino]methyl)phenol
2.7.11.24 additional information
-
 relative activity, 56% of control Solanum peruvianum 2-(2-[[6-(benzylamino)-9-(1-methylethyl)-9H-purin-2-yl]amino]ethoxy)ethanol
2.7.11.24 additional information
-
 relative activity, 56% of control Solanum peruvianum N-methyl-9-(1-methylethyl)-9H-purin-6-amine
2.7.11.24 additional information
-
 relative activity, 57% of control Solanum peruvianum olomucine
2.7.11.24 additional information
-
 relative activity, 58% of control Solanum peruvianum (2S)-2-([6-[(2-aminobenzyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino)butan-1-ol
2.7.11.24 additional information
-
 relative activity, 58% of control Solanum peruvianum 3-([[2-(heptylamino)-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl)phenol
2.7.11.24 additional information
-
 relative activity, 62% of control Solanum peruvianum 3-([[2-[[1-(hydroxymethyl)-2-methylbutyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl)phenol
2.7.11.24 additional information
-
 relative activity, 67% of control Solanum peruvianum 2-([[9-(1-methylethyl)-2-(4-prop-2-yn-1-ylpiperazin-1-yl)-9H-purin-6-yl]amino]methyl)phenol
2.7.11.24 additional information
-
 relative activity, 69% of control Solanum peruvianum N-benzyl-9-(1-methylethyl)-2-(methylsulfanyl)-9H-purin-6-amine
2.7.11.24 additional information
-
 relative activity, 91% of control Solanum peruvianum N-benzyl-9-methyl-2-morpholin-4-yl-9H-purin-6-amine
2.7.11.24 additional information
-
 relative activity, 96% of control Solanum peruvianum 2-([6-[(3-methylbut-2-en-1-yl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino)ethanol