EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.1.3.13 | 1-(3-(5-allyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfonyl)-propyl)-1H-benzo[d]imidazol-2(3H)-one | - |
Mycobacterium tuberculosis | |
5.1.3.13 | 1-(3-(5-allyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one | i.e. 77074, a SID 7975595 analogue | Mycobacterium tuberculosis | |
5.1.3.13 | 1-(3-(5-allyl-8-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one | - |
Mycobacterium tuberculosis | |
5.1.3.13 | 1-(3-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfonyl)-propyl)-1H-benzo[d]imidazol-2(3H)-one | - |
Mycobacterium tuberculosis | |
5.1.3.13 | 1-(3-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one | i.e. SID 7975595, a competitive, fast-on rate, fully reversible inhibitor of RmlC. Increases the Km for TDP-6-deoxy-D-xylo-hexopyranosid-4-ulose. Cytotoxic SID 7975595 has an IC50 of approximately 0.075 mM in HAE cells | Mycobacterium tuberculosis | |
5.1.3.13 | 1-(3-(5-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one | i.e. 77072, a SID 7975595 analogue | Mycobacterium tuberculosis | |
5.1.3.13 | 1-(3-(5-methylphenyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one | i.e. 77070, a SID 7975595 analogue | Mycobacterium tuberculosis | |
5.1.3.13 | 1-(3-(5-propyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one | i.e. 77071, a SID 7975595 analogue | Mycobacterium tuberculosis | |
5.1.3.13 | 1-(3-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one | i.e. 77073, a SID 7975595 analogue | Mycobacterium tuberculosis | |
5.1.3.13 | additional information | modeling of triazinoindol-benzimidazolones into the active site of RmlC, overview | Mycobacterium tuberculosis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
5.1.3.13 | additional information | - |
additional information | Michaelis-Menten kinetics | Mycobacterium tuberculosis |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
5.1.3.13 | cell wall | - |
Mycobacterium tuberculosis | 5618 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
5.1.3.13 | Mg2+ | - |
Mycobacterium tuberculosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.1.3.13 | TDP-6-deoxy-D-xylo-hexopyranosid-4-ulose | Mycobacterium tuberculosis | conversion of TDP-6-deoxy-D-xylo-hexopyranosid-4-ulose to TDP-L-rhamnose, catalyzed by the two enzymes TDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase, RmlC, and TDP-deoxy-L-lyxo-4-hexulose reductase, RmlD, overview | TDP-L-rhamnose | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.1.3.13 | Mycobacterium tuberculosis | P9WH11 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.1.3.13 | TDP-6-deoxy-D-xylo-hexopyranosid-4-ulose | conversion of TDP-6-deoxy-D-xylo-hexopyranosid-4-ulose to TDP-L-rhamnose, catalyzed by the two enzymes TDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase, RmlC, and TDP-deoxy-L-lyxo-4-hexulose reductase, RmlD, overview | Mycobacterium tuberculosis | TDP-L-rhamnose | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.1.3.13 | RmlC | - |
Mycobacterium tuberculosis |
5.1.3.13 | TDP-6-deoxy-D-xylo-4-hexopyranosid-4-ulose 3,5-epimerase | - |
Mycobacterium tuberculosis |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
5.1.3.13 | 25 | - |
assay at | Mycobacterium tuberculosis |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
5.1.3.13 | 7.4 | - |
assay at | Mycobacterium tuberculosis |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
5.1.3.13 | 0.00012 | - |
- |
Mycobacterium tuberculosis | 1-(3-(5-allyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one | |
5.1.3.13 | 0.0002 | - |
pH 7.4, 25°C | Mycobacterium tuberculosis | 1-(3-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one | |
5.1.3.13 | 0.0004 | - |
pH 7.4, 25°C | Mycobacterium tuberculosis | 1-(3-(5-allyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfonyl)-propyl)-1H-benzo[d]imidazol-2(3H)-one | |
5.1.3.13 | 0.0005 | - |
pH 7.4, 25°C | Mycobacterium tuberculosis | 1-(3-(5-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one | |
5.1.3.13 | 0.0008 | - |
pH 7.4, 25°C | Mycobacterium tuberculosis | 1-(3-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfonyl)-propyl)-1H-benzo[d]imidazol-2(3H)-one | |
5.1.3.13 | 0.00125 | - |
pH 7.4, 25°C | Mycobacterium tuberculosis | 1-(3-(5-propyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one | |
5.1.3.13 | 0.0029 | - |
pH 7.4, 25°C | Mycobacterium tuberculosis | 1-(3-(5-methylphenyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one | |
5.1.3.13 | 0.0033 | - |
pH 7.4, 25°C | Mycobacterium tuberculosis | 1-(3-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one | |
5.1.3.13 | 0.02 | - |
- |
Mycobacterium tuberculosis | 1-(3-(5-allyl-8-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)propyl)-1H-benzo[d]imidazol-2(3H)-one |