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Literature summary extracted from

  • Innocenti, A.; Hall, R.A.; Scozzafava, A.; Muehlschlegel, F.A.; Supuran, C.T.
    Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids (2010), Bioorg. Med. Chem., 18, 1034-1037.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.2.1.1 1-(2-aminoethyl)-piperazine
-
 Cryptococcus neoformans
4.2.1.1 1-(2-aminoethyl)-piperazine
-
 Candida albicans
4.2.1.1 2-(2-aminoethyl)pyridine
-
 Cryptococcus neoformans
4.2.1.1 2-(2-aminoethyl)pyridine
-
 Candida albicans
4.2.1.1 2-pyridyl-methylamine
-
 Cryptococcus neoformans
4.2.1.1 2-pyridyl-methylamine
-
 Candida albicans
4.2.1.1 4-(2-aminoethyl)-morpholine
-
 Cryptococcus neoformans
4.2.1.1 4-(2-aminoethyl)-morpholine
-
 Candida albicans
4.2.1.1 4-amino-L-phenylalanine
-
 Cryptococcus neoformans
4.2.1.1 4-amino-L-phenylalanine
-
 Candida albicans
4.2.1.1 D-Dopa
-
 Cryptococcus neoformans
4.2.1.1 D-Dopa best activator of CaNce103 Candida albicans
4.2.1.1 D-His
-
 Cryptococcus neoformans
4.2.1.1 D-His
-
 Candida albicans
4.2.1.1 D-Phe micromolar affinity for Can2 Cryptococcus neoformans
4.2.1.1 D-Phe micromolar affinity for CANce103 Candida albicans
4.2.1.1 D-Trp
-
 Cryptococcus neoformans
4.2.1.1 D-Trp
-
 Candida albicans
4.2.1.1 dopamine
-
 Cryptococcus neoformans
4.2.1.1 dopamine
-
 Candida albicans
4.2.1.1 histamine
-
 Cryptococcus neoformans
4.2.1.1 histamine
-
 Candida albicans
4.2.1.1 L-adrenaline
-
 Cryptococcus neoformans
4.2.1.1 L-adrenaline
-
 Candida albicans
4.2.1.1 L-Dopa
-
 Cryptococcus neoformans
4.2.1.1 L-Dopa best activator of CaNce103 Candida albicans
4.2.1.1 L-His
-
 Cryptococcus neoformans
4.2.1.1 L-His
-
 Candida albicans
4.2.1.1 L-Phe
-
 Cryptococcus neoformans
4.2.1.1 L-Phe
-
 Candida albicans
4.2.1.1 L-Trp
-
 Cryptococcus neoformans
4.2.1.1 L-Trp best Can2 activator Cryptococcus neoformans
4.2.1.1 L-Trp
-
 Candida albicans
4.2.1.1 L-Tyr
-
 Cryptococcus neoformans
4.2.1.1 L-Tyr
-
 Candida albicans
4.2.1.1 serotonin
-
 Cryptococcus neoformans
4.2.1.1 serotonin
-
 Candida albicans

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.1 8.2
-
 CO2 CaNce103, at 25°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 9
-
 CO2 Can2, at 25°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Candida albicans
-
-
-
4.2.1.1 Cryptococcus neoformans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 CO2 + H2O
-
 Cryptococcus neoformans H2CO3
-
 r
4.2.1.1 CO2 + H2O
-
 Candida albicans H2CO3
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 Can2
-
 Cryptococcus neoformans
4.2.1.1 CaNce103
-
 Candida albicans
4.2.1.1 carbonic anhydrase
-
 Cryptococcus neoformans
4.2.1.1 carbonic anhydrase
-
 Candida albicans

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.1.1 390000
-
 CO2 Can2, at 25°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Cryptococcus neoformans
4.2.1.1 680000
-
 CO2 Can2, at 25°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4, in the presence of 0.01 mM histamine Cryptococcus neoformans
4.2.1.1 800000
-
 CO2 CaNce103, at 25°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 Candida albicans
4.2.1.1 2010000
-
 CO2 CaNce103, at 25°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4, in the presence of 0.01 mM histamine Candida albicans