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Literature summary extracted from

  • Cagnoni, A.J.; Uhrig, M.L.; Varela, O.
    Synthesis of pentopyranosyl-containing thiodisaccharides. Inhibitory activity against beta-glycosidases (2009), Bioorg. Med. Chem., 17, 6203-6212.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.21 additional information not inhibited by 2-propyl 3-deoxy-4-S-(beta-D-xylopyranosyl)-4-thio-alpha-D-xylohexopyranoside and 2-propyl 3-deoxy-4-S-(beta-D-xylopyranosyl)-4-thio-alpha-D-xylo-hexopyranoside Prunus dulcis
3.2.1.23 benzyl 3-deoxy-4-S-(beta-D-galactopyranosyl)-4-thio-beta-D-erythro-pentopyranoside non-competitive inhibitor Escherichia coli
3.2.1.23 benzyl 3-deoxy-4-S-(beta-D-galactopyranosyl)-4-thio-beta-D-threo-pentopyranoside mixed-type inhibitor Escherichia coli
3.2.1.23 additional information not inhibited by 2-propyl 3-deoxy-4-S-(beta-D-xylopyranosyl)-4-thio-alpha-D-xylohexopyranoside and 2-propyl 3-deoxy-4-S-(beta-D-xylopyranosyl)-4-thio-alpha-D-lyxohexopyranoside Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.21 Prunus dulcis
-
-
-
3.2.1.23 Escherichia coli
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.21 seed
-
 Prunus dulcis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.21 4-nitrophenyl beta-D-glucopyranoside + H2O
-
 Prunus dulcis 4-nitrophenol + D-glucopyranose
-
 ?
3.2.1.23 2-nitrophenyl beta-D-galactopyranoside + H2O
-
 Escherichia coli 2-nitrophenol + beta-D-galactose
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.1.23 0.032
-
 benzyl 3-deoxy-4-S-(beta-D-galactopyranosyl)-4-thio-beta-D-threo-pentopyranoside in sodium phosphate buffer (100 mM, pH 7.3, MgCl2 1.2 mM, beta-mercaptoethanol 100 mM) Escherichia coli
3.2.1.23 0.8
-
 benzyl 3-deoxy-4-S-(beta-D-galactopyranosyl)-4-thio-beta-D-erythro-pentopyranoside in sodium phosphate buffer (100 mM, pH 7.3, MgCl2 1.2 mM, beta-mercaptoethanol 100 mM) Escherichia coli