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Literature summary extracted from

  • Lee, J.Y.; Jeong, K.W.; Shin, S.; Lee, J.U.; Kim, Y.
    Antimicrobial natural products as beta-ketoacyl-acyl carrier protein synthase III inhibitors (2009), Bioorg. Med. Chem., 17, 5408-5413.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.180 gene fabH, expression in Escherichia coli strain BL21(DE3) Escherichia coli K-12

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.180 3,6-dihydroxyflavone i.e. YKAF01 Escherichia coli K-12
2.3.1.180 3-(4-hydroxyphenyl)-1-(2,4,6-tri-hydroxyphenyl)propan-1-one i.e. YKAF04, or 4,2',4',6'-tetrahydroxychalcone, or phloretin Escherichia coli K-12
2.3.1.180 additional information inhibitor structure analysis by NMR, binding analysis, and antibacterial activities, overview Escherichia coli K-12

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] Escherichia coli K-12
-
 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.180 Escherichia coli K-12
-
 gene fabH
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein]
-
 Escherichia coli K-12 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.180 beta-ketoacyl-acyl carrier protein synthase III
-
 Escherichia coli K-12
2.3.1.180 KAS III
-
 Escherichia coli K-12

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.180 8
-
 assay at Escherichia coli K-12