BRENDA - Enzyme Database show

Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides

Bertucci, A.; Innocenti, A.; Zoccola, D.; Scozzafava, A.; Tambutte, S.; Supuran, C.T.; Bioorg. Med. Chem. 17, 5054-5058 (2009)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.1
2-aminobenzenesulfonamide
-
Stylophora pistillata
4.2.1.1
2-hydrazinylbenzenesulfonamide
-
Stylophora pistillata
4.2.1.1
3-(4-sulfamoylphenyl)propanoic acid
-
Stylophora pistillata
4.2.1.1
4-(2-aminoethyl)benzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-(2-hydroxyethyl)benzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-(aminomethyl)benzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-(hydroxymethyl)benzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-amino-3-bromobenzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-amino-3-chlorobenzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-amino-3-fluorobenzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-amino-3-iodobenzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
Stylophora pistillata
4.2.1.1
4-amino-6-chlorobenzene-1,3-disulfonamide
-
Stylophora pistillata
4.2.1.1
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-Aminobenzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-methylbenzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-sulfamoylbenzoic acid
-
Stylophora pistillata
4.2.1.1
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
Stylophora pistillata
4.2.1.1
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
Stylophora pistillata
4.2.1.1
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
Stylophora pistillata
4.2.1.1
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
Stylophora pistillata
4.2.1.1
acetazolamide
-
Stylophora pistillata
4.2.1.1
benzolamide
-
Stylophora pistillata
4.2.1.1
brinzolamide
-
Stylophora pistillata
4.2.1.1
celecoxib
-
Stylophora pistillata
4.2.1.1
dichlorophenamide
-
Stylophora pistillata
4.2.1.1
dorzolamide
-
Stylophora pistillata
4.2.1.1
ethoxzolamide
-
Stylophora pistillata
4.2.1.1
indisulam
-
Stylophora pistillata
4.2.1.1
methazolamide
-
Stylophora pistillata
4.2.1.1
saccharin
effective STPCA inhibitor
Stylophora pistillata
4.2.1.1
sulpiride
-
Stylophora pistillata
4.2.1.1
sulthiame
-
Stylophora pistillata
4.2.1.1
topiramate
-
Stylophora pistillata
4.2.1.1
valdecoxib
-
Stylophora pistillata
4.2.1.1
zonisamide
-
Stylophora pistillata
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.2.1.1
CO2 + H2O
Stylophora pistillata
-
H2CO3
-
-
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.2.1.1
Stylophora pistillata
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.1
CO2 + H2O
-
702655
Stylophora pistillata
H2CO3
-
-
-
r
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
4.2.1.1
0.000016
-
acetazolamide
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000181
-
dorzolamide
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000197
-
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000204
-
benzolamide
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000212
-
methazolamide
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000254
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000276
-
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000287
-
valdecoxib
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000291
-
topiramate
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000298
-
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000342
-
celecoxib
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000394
-
ethoxzolamide
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000403
-
saccharin
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000452
-
sulthiame
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000482
-
brinzolamide
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000751
-
4-amino-3-fluorobenzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000825
-
4-(aminomethyl)benzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000875
-
4-amino-3-chlorobenzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000883
-
4-amino-3-iodobenzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000919
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000943
-
4-(2-aminoethyl)benzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000104
-
4-amino-3-bromobenzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000105
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000163
-
indisulam
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.000256
-
3-(4-sulfamoylphenyl)propanoic acid
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000259
-
zonisamide
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.000295
-
4-amino-6-chlorobenzene-1,3-disulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000364
-
4-Aminobenzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000367
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.00043
-
sulpiride
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.000431
-
dichlorophenamide
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.000435
-
4-sulfamoylbenzoic acid
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000553
-
2-aminobenzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000614
-
4-methylbenzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000768
-
4-(hydroxymethyl)benzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.00077
-
4-(2-hydroxyethyl)benzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.00251
-
2-hydrazinylbenzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.2.1.1
2-aminobenzenesulfonamide
-
Stylophora pistillata
4.2.1.1
2-hydrazinylbenzenesulfonamide
-
Stylophora pistillata
4.2.1.1
3-(4-sulfamoylphenyl)propanoic acid
-
Stylophora pistillata
4.2.1.1
4-(2-aminoethyl)benzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-(2-hydroxyethyl)benzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-(aminomethyl)benzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-(hydroxymethyl)benzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-amino-3-bromobenzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-amino-3-chlorobenzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-amino-3-fluorobenzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-amino-3-iodobenzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
Stylophora pistillata
4.2.1.1
4-amino-6-chlorobenzene-1,3-disulfonamide
-
Stylophora pistillata
4.2.1.1
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-Aminobenzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-methylbenzenesulfonamide
-
Stylophora pistillata
4.2.1.1
4-sulfamoylbenzoic acid
-
Stylophora pistillata
4.2.1.1
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
Stylophora pistillata
4.2.1.1
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
Stylophora pistillata
4.2.1.1
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
Stylophora pistillata
4.2.1.1
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
Stylophora pistillata
4.2.1.1
acetazolamide
-
Stylophora pistillata
4.2.1.1
benzolamide
-
Stylophora pistillata
4.2.1.1
brinzolamide
-
Stylophora pistillata
4.2.1.1
celecoxib
-
Stylophora pistillata
4.2.1.1
dichlorophenamide
-
Stylophora pistillata
4.2.1.1
dorzolamide
-
Stylophora pistillata
4.2.1.1
ethoxzolamide
-
Stylophora pistillata
4.2.1.1
indisulam
-
Stylophora pistillata
4.2.1.1
methazolamide
-
Stylophora pistillata
4.2.1.1
saccharin
effective STPCA inhibitor
Stylophora pistillata
4.2.1.1
sulpiride
-
Stylophora pistillata
4.2.1.1
sulthiame
-
Stylophora pistillata
4.2.1.1
topiramate
-
Stylophora pistillata
4.2.1.1
valdecoxib
-
Stylophora pistillata
4.2.1.1
zonisamide
-
Stylophora pistillata
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
4.2.1.1
0.000016
-
acetazolamide
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000181
-
dorzolamide
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000197
-
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000204
-
benzolamide
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000212
-
methazolamide
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000254
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000276
-
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000287
-
valdecoxib
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000291
-
topiramate
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000298
-
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000342
-
celecoxib
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000394
-
ethoxzolamide
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000403
-
saccharin
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000452
-
sulthiame
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000482
-
brinzolamide
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.0000751
-
4-amino-3-fluorobenzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000825
-
4-(aminomethyl)benzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000875
-
4-amino-3-chlorobenzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000883
-
4-amino-3-iodobenzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000919
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.0000943
-
4-(2-aminoethyl)benzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000104
-
4-amino-3-bromobenzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000105
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000163
-
indisulam
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.000256
-
3-(4-sulfamoylphenyl)propanoic acid
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000259
-
zonisamide
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.000295
-
4-amino-6-chlorobenzene-1,3-disulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000364
-
4-Aminobenzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000367
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.00043
-
sulpiride
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.000431
-
dichlorophenamide
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
Stylophora pistillata
4.2.1.1
0.000435
-
4-sulfamoylbenzoic acid
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000553
-
2-aminobenzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000614
-
4-methylbenzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.000768
-
4-(hydroxymethyl)benzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.00077
-
4-(2-hydroxyethyl)benzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
4.2.1.1
0.00251
-
2-hydrazinylbenzenesulfonamide
in 10 mM HEPES (pH 7.4), at 25°C
Stylophora pistillata
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.2.1.1
CO2 + H2O
Stylophora pistillata
-
H2CO3
-
-
r
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.1
CO2 + H2O
-
702655
Stylophora pistillata
H2CO3
-
-
-
r