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Literature summary extracted from

  • Karis, N.D.; Loughlin, W.A.; Jenkins, I.D.; Healy, P.C.
    Glycogen phosphorylase inhibitory effects of 2-oxo-1,2-dihydropyridin-3-yl amide derivatives (2009), Bioorg. Med. Chem., 17, 4724-4733.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.1 2-[3'-(benzylamino)-2'-oxopyridin-1'(2H)-yl]-N-(3'',4''-dichlorobenzyl)acetamide
-
 Oryctolagus cuniculus
2.4.1.1 N-benzyl-2-[3'-(benzylamino)-2'-oxopyridin-1'(2H)-yl]acetamide
-
 Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.1 Oryctolagus cuniculus
-
 glycogen phosphorylase a
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.1 commercial preparation
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.1 glycogen + phosphate
-
 Oryctolagus cuniculus glycogen + alpha-D-glucose 1-phosphate
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.1.1 0.0063
-
 pH 7.2, 22°C Oryctolagus cuniculus 2-[3'-(benzylamino)-2'-oxopyridin-1'(2H)-yl]-N-(3'',4''-dichlorobenzyl)acetamide
2.4.1.1 0.0342
-
 pH 7.2, 22°C Oryctolagus cuniculus N-benzyl-2-[3'-(benzylamino)-2'-oxopyridin-1'(2H)-yl]acetamide