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Literature summary extracted from

  • Reddy, M.V.; Billa, V.K.; Pallela, V.R.; Mallireddigari, M.R.; Boominathan, R.; Gabriel, J.L.; Reddy, E.P.
    Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors (2008), Bioorg. Med. Chem., 16, 3907-3916.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.31 4-[5-(1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide 0.01 mM inhibits LOX-12 by 5% Homo sapiens
1.13.11.31 4-[5-(7-chloro-1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide 0.01 mM inhibits LOX-12 by 3% Homo sapiens
1.13.11.31 celecoxib 0.01 mM inhibits LOX-12 by 7% Homo sapiens
1.13.11.31 additional information 0.01 mM 4-[5-(6-chloro-1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide or rofecoxib do not inhibit LOX-12 Homo sapiens
1.13.11.34 4-[5-(1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide 0.01 mM inhibits LOX-5 by 41% Homo sapiens
1.13.11.34 4-[5-(1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide 0.01 mM inhibits LOX-15 by 31% Oryctolagus cuniculus
1.13.11.34 4-[5-(6-chloro-1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide 0.01 mM inhibits LOX-5 by 51% Homo sapiens
1.13.11.34 4-[5-(6-chloro-1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide 0.01 mM inhibits LOX-15 by 36% Oryctolagus cuniculus
1.13.11.34 4-[5-(7-chloro-1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide 0.01 mM inhibits LOX-5 by 94% Homo sapiens
1.13.11.34 4-[5-(7-chloro-1H-indol-3-yl)-3-trifluoromethyl-4,5-dihydropyrazol-1-yl]-benzenesulfonamide 0.01 mM inhibits LOX-15 by 36% Oryctolagus cuniculus
1.13.11.34 celecoxib 0.01 mM inhibits LOX-5 by 89% Homo sapiens
1.13.11.34 celecoxib 0.01 mM inhibits LOX-15 by 22% Oryctolagus cuniculus
1.13.11.34 rofecoxib 0.01 mM inhibits LOX-5 by 11% Homo sapiens
1.13.11.34 rofecoxib 0.01 mM inhibits LOX-15 by 6% Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.31 Homo sapiens
-
-
-
1.13.11.34 Homo sapiens
-
-
-
1.13.11.34 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.31 blood platelet
-
 Homo sapiens
-
1.13.11.34 additional information PBML cells Homo sapiens
-
1.13.11.34 reticulocyte LOX-15 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.31 arachidonate + O2
-
 Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?
1.13.11.31 linoleate + O2
-
 Homo sapiens (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
 ?
1.13.11.34 arachidonate + O2
-
 Homo sapiens (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?
1.13.11.34 arachidonate + O2
-
 Oryctolagus cuniculus (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.31 lipoxygenase 12
-
 Homo sapiens
1.13.11.31 LOX-12
-
 Homo sapiens
1.13.11.34 lipoxygenase 15
-
 Oryctolagus cuniculus
1.13.11.34 lipoxygenase 5
-
 Homo sapiens
1.13.11.34 LOX-15
-
 Oryctolagus cuniculus
1.13.11.34 LOX-5
-
 Homo sapiens