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Literature summary extracted from

  • Kumar, R.; Srivastava, R.; Singh, R.; Surolia, A.; Rao, D.
    Activation and inhibition of DNA methyltransferases by S-adenosyl-L-homocysteine analogues (2008), Bioorg. Med. Chem., 16, 2276-2285.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.72 5'-S-(propionic acid)5'-deoxy-9-(1'-beta-D-ribofuranosyl)1,3-dideazaadenine more than 200% activity in the presence of 0.015 mM 5'-S-(propionic acid)5'-deoxy-9-(1'-beta-D-ribofuranosyl)1,3-dideazaadenine Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.72 5'-S-(2-carboxyethyl)-5'-thioadenosine non-competitive inhibition Escherichia coli
2.1.1.72 additional information 5'-allylthio-5'-deoxy-9-(1'-beta-D-ribofuranosyl)6-nitrodideazaadenine, 5'-chloro-5'-deoxyadenosine, 9-(1'-beta-D-ribofuranosyl)6-nitro-1,3-dideazaadenine, 5'-S-(propionamide)5'-deoxy-9-(1'-beta-D-ribofuranosyl)-adenine, 5'-S-(ethylpropionate)5'-deoxy-9-(1'-beta-D-ribofuranosyl)adenine, 5'-S-5'-methylthio deoxyadenosine, 5'-S-propargylthio adenosine, 5'-S-allenylthio adenosine, and 5'-S-propynylthioadenosine have no effect on M.EcoP15I activity Escherichia coli
2.1.1.72 S-adenosyl-L-homocysteine strong inhibition Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.72 S-adenosyl-L-methionine + DNA adenine Escherichia coli
-
 S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.72 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.72 S-adenosyl-L-methionine + DNA adenine
-
 Escherichia coli S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.72 Dam
-
 Escherichia coli
2.1.1.72 DNA adenine methyltransferases
-
 Escherichia coli
2.1.1.72 EcoP15I
-
 Escherichia coli
2.1.1.72 M.EcoP15I
-
 Escherichia coli
2.1.1.72 N6 adenine MTase
-
 Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.72 0.005
-
 5'-S-(2-carboxyethyl)-5'-thioadenosine
-
 Escherichia coli

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.1.1.72 0.005
-
-
 Escherichia coli 5'-S-(2-carboxyethyl)-5'-thioadenosine