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Literature summary extracted from

  • Ryu, Y.B.; Kim, J.H.; Park, S.J.; Chang, J.S.; Rho, M.C.; Bae, K.H.; Park, K.H.; Lee, W.S.
    Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis (2010), Bioorg. Med. Chem. Lett., 20, 971-974.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.18 2'-methoxy-isoliquiritigenin
-
 unidentified influenza virus
3.2.1.18 2'-methoxyisoliquiritigenin noncompetitive inhibition unidentified influenza virus
3.2.1.18 glyasperin C 20% inhibition at 0.2 mM unidentified influenza virus
3.2.1.18 glyasperin D 20% inhibition at 0.2 mM unidentified influenza virus
3.2.1.18 glycyrin 10% inhibition at 0.2 mM unidentified influenza virus
3.2.1.18 glycyrol strong inhibitory activity, noncompetitive inhibition unidentified influenza virus
3.2.1.18 isoglycyrol noncompetitive inhibition unidentified influenza virus
3.2.1.18 isoliquiritigenin strong inhibitory activity, noncompetitive inhibition unidentified influenza virus
3.2.1.18 isoliquiritin noncompetitive inhibition unidentified influenza virus
3.2.1.18 isoliquiritin apioside noncompetitive inhibition unidentified influenza virus
3.2.1.18 kumatakenin noncompetitive inhibition unidentified influenza virus
3.2.1.18 licocoumarone noncompetitive inhibition unidentified influenza virus
3.2.1.18 licoflavonol noncompetitive inhibition unidentified influenza virus
3.2.1.18 licopyranocoumarin 10% inhibition at 0.2 mM unidentified influenza virus
3.2.1.18 licorisoflavan A 30% inhibition at 0.2 mM unidentified influenza virus
3.2.1.18 liquiritigenin noncompetitive inhibition unidentified influenza virus
3.2.1.18 liquiritin noncompetitive inhibition unidentified influenza virus
3.2.1.18 liquiritin apioside noncompetitive inhibition unidentified influenza virus
3.2.1.18 ononin 30% inhibition at 0.2 mM unidentified influenza virus

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.18 unidentified influenza virus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.18 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O
-
 unidentified influenza virus 4-methylumbelliferone + N-acetylneuraminic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.18 neuraminidase
-
 unidentified influenza virus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.18 0.0031
-
-
 unidentified influenza virus glycyrol
3.2.1.18 0.009
-
-
 unidentified influenza virus isoliquiritigenin
3.2.1.18 0.0129
-
-
 unidentified influenza virus isoliquiritin apioside
3.2.1.18 0.0182
-
-
 unidentified influenza virus liquiritin apioside
3.2.1.18 0.0206
-
-
 unidentified influenza virus licoflavonol
3.2.1.18 0.0243
-
-
 unidentified influenza virus 2'-methoxy-isoliquiritigenin
3.2.1.18 0.0278
-
-
 unidentified influenza virus licocoumarone
3.2.1.18 0.0364
-
-
 unidentified influenza virus kumatakenin
3.2.1.18 0.0468
-
-
 unidentified influenza virus liquiritigenin
3.2.1.18 0.0823
-
-
 unidentified influenza virus liquiritin
3.2.1.18 0.0924
-
-
 unidentified influenza virus isoglycyrol
3.2.1.18 0.124
-
-
 unidentified influenza virus isoliquiritin