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Literature summary extracted from

  • Tao, Y.H.; Xu, H.B.; Yang, X.L.
    Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one (2009), Bioorg. Med. Chem. Lett., 19, 731-734.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.19 (Z)-4-amino-2-butenoic acid
-
 Homo sapiens
2.6.1.19 3-chloro-1-(4-hydroxyphenyl)propan-1-one irreversible and potent inhibitor, about 30% residual activity at 0.06 mM, 2-oxoglutarate prevents the enzyme from inactivation Homo sapiens
2.6.1.19 4-hydroxybenzaldehyde competitive inhibitor of GABA transaminase Homo sapiens
2.6.1.19 vigabatrin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.19 4-aminobutanoate + 2-oxoglutarate
-
 Homo sapiens 4-oxobutanoate + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.19 GABA transaminase
-
 Homo sapiens
2.6.1.19 GABA-T
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.19 pyridoxal 5'-phosphate
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.6.1.19 0.00399
-
-
 Homo sapiens 3-chloro-1-(4-hydroxyphenyl)propan-1-one
2.6.1.19 0.0165
-
-
 Homo sapiens 4-hydroxybenzaldehyde