BRENDA - Enzyme Database show

5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase

Tarver, J.E.; Jessop, T.C.; Carlsen, M.; Augeri, D.J.; Fu, Q.; Healy, J.P.; Heim-Riether, A.; Xu, A.; Taylor, J.A.; Shen, M.; Keyes, P.E.; David Kimball, S.; Yu, X.C.; Miranda, M.; Liu, Q.; Swaffield, J.C.; Nouraldeen, A.; Wilson, A.G.; Finch, R.; Jhaver, K.; Foushee, A.M.; Anderson, S.; Oravecz, T.; Carson, K.G.; Bioorg. Med. Chem. Lett. 19, 6780-6783 (2009)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.74
2'-deoxy-5-fluorocytidine
-
Mus musculus
2.7.1.74
2-(2-[1-[6-(1-benzothiophen-2-yl)pyrimidin-4-yl]piperidin-4-yl]ethoxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([1-[6-(1-benzothiophen-2-yl)pyrimidin-4-yl]piperidin-4-yl]methoxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([1-[6-(1-benzothiophen-2-yl)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([1-[6-(2-chlorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([1-[6-(2-ethylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([1-[6-(3-chlorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([1-[6-(4-chloro-2-methylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([1-[6-(4-chlorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([1-[6-(biphenyl-2-yloxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([6-[4-(4-amino-2-oxopyrimidin-1(2H)-yl)piperidin-1-yl]-5-fluoropyrimidin-4-yl]oxy)benzonitrile
-
Mus musculus
2.7.1.74
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-2-bromopyrimidin-4-yl)oxy]benzonitrile
-
Mus musculus
2.7.1.74
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-2-methylpyrimidin-4-yl)oxy]benzonitrile
-
Mus musculus
2.7.1.74
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]-5-methoxybenzonitrile
-
Mus musculus
2.7.1.74
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]benzonitrile
-
Mus musculus
2.7.1.74
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-methylpyrimidin-4-yl)oxy]benzonitrile
-
Mus musculus
2.7.1.74
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]pyrimidin-4-yl)oxy]-5-methoxybenzonitrile
-
Mus musculus
2.7.1.74
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]pyrimidin-4-yl)oxy]benzonitrile
-
Mus musculus
2.7.1.74
2-[(6-[4-[(4-aminopyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]benzonitrile
-
Mus musculus
2.7.1.74
2-[[6-(1-benzothiophen-2-yl)pyrimidin-4-yl]oxy]-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
3-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-2-fluoropyrimidin-4-yl)oxy]-4-methoxybenzonitrile
-
Mus musculus
2.7.1.74
3-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]-4-methoxybenzonitrile
-
Mus musculus
2.7.1.74
3-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]benzonitrile
-
Mus musculus
2.7.1.74
3-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]pyrimidin-4-yl)oxy]benzonitrile
-
Mus musculus
2.7.1.74
4-(1-benzothiophen-2-yl)-6-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]pyrimidine
-
Mus musculus
2.7.1.74
5-fluoro-2-([1-[5-fluoro-6-(4-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
-
Mus musculus
2.7.1.74
5-fluoro-2-([1-[6-(2-fluorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
-
Mus musculus
2.7.1.74
5-fluoro-2-([1-[6-(2-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
-
Mus musculus
2.7.1.74
5-fluoro-2-([1-[6-(2-methylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
-
Mus musculus
2.7.1.74
5-fluoro-2-([1-[6-(3-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
-
Mus musculus
2.7.1.74
5-fluoro-2-([1-[6-(4-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
-
Mus musculus
2.7.1.74
5-fluoro-2-([1-[6-(4-methylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
-
Mus musculus
2.7.1.74
5-fluoro-2-[[1-(6-phenoxypyrimidin-4-yl)piperidin-4-yl]oxy]pyrimidin-4-amine
-
Mus musculus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.74
Mus musculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
spleen
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
702603
Mus musculus
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Mus musculus
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
2.7.1.74
0.0000007
-
-
Mus musculus
2-[(6-[4-[(4-aminopyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]benzonitrile
2.7.1.74
0.000001
-
-
Mus musculus
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]benzonitrile
2.7.1.74
0.000001
-
-
Mus musculus
3-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-2-fluoropyrimidin-4-yl)oxy]-4-methoxybenzonitrile
2.7.1.74
0.000002
-
-
Mus musculus
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]-5-methoxybenzonitrile
2.7.1.74
0.000003
-
-
Mus musculus
2-([1-[6-(2-chlorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.000003
-
-
Mus musculus
2-([1-[6-(biphenyl-2-yloxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.000003
-
-
Mus musculus
2-(2-[1-[6-(1-benzothiophen-2-yl)pyrimidin-4-yl]piperidin-4-yl]ethoxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.000003
-
-
Mus musculus
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]pyrimidin-4-yl)oxy]-5-methoxybenzonitrile
2.7.1.74
0.000003
-
-
Mus musculus
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]pyrimidin-4-yl)oxy]benzonitrile
2.7.1.74
0.000004
-
-
Mus musculus
3-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]benzonitrile
2.7.1.74
0.000004
-
-
Mus musculus
5-fluoro-2-([1-[5-fluoro-6-(4-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
2.7.1.74
0.000005
-
-
Mus musculus
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-2-bromopyrimidin-4-yl)oxy]benzonitrile
2.7.1.74
0.000005
-
-
Mus musculus
3-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]-4-methoxybenzonitrile
2.7.1.74
0.000005
-
-
Mus musculus
5-fluoro-2-([1-[6-(2-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
2.7.1.74
0.000006
-
-
Mus musculus
5-fluoro-2-([1-[6-(2-fluorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
2.7.1.74
0.000009
-
-
Mus musculus
2-([1-[6-(4-chloro-2-methylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.000009
-
-
Mus musculus
5-fluoro-2-([1-[6-(2-methylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
2.7.1.74
0.00001
-
-
Mus musculus
2-([1-[6-(2-ethylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.00001
-
-
Mus musculus
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-2-methylpyrimidin-4-yl)oxy]benzonitrile
2.7.1.74
0.000013
-
-
Mus musculus
3-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]pyrimidin-4-yl)oxy]benzonitrile
2.7.1.74
0.000019
-
-
Mus musculus
2-([1-[6-(4-chlorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.000021
-
-
Mus musculus
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-methylpyrimidin-4-yl)oxy]benzonitrile
2.7.1.74
0.000021
-
-
Mus musculus
5-fluoro-2-([1-[6-(4-methylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
2.7.1.74
0.000022
-
-
Mus musculus
2-([1-[6-(3-chlorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.000023
-
-
Mus musculus
5-fluoro-2-([1-[6-(3-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
2.7.1.74
0.000033
-
-
Mus musculus
5-fluoro-2-([1-[6-(4-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
2.7.1.74
0.000034
-
-
Mus musculus
2-([1-[6-(1-benzothiophen-2-yl)pyrimidin-4-yl]piperidin-4-yl]methoxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.000038
-
-
Mus musculus
2-([1-[6-(1-benzothiophen-2-yl)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.000063
-
-
Mus musculus
2-([6-[4-(4-amino-2-oxopyrimidin-1(2H)-yl)piperidin-1-yl]-5-fluoropyrimidin-4-yl]oxy)benzonitrile
2.7.1.74
0.000095
-
-
Mus musculus
5-fluoro-2-[[1-(6-phenoxypyrimidin-4-yl)piperidin-4-yl]oxy]pyrimidin-4-amine
2.7.1.74
0.00012
-
-
Mus musculus
2'-deoxy-5-fluorocytidine
2.7.1.74
0.00051
-
-
Mus musculus
4-(1-benzothiophen-2-yl)-6-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]pyrimidine
2.7.1.74
0.00072
-
-
Mus musculus
2-[[6-(1-benzothiophen-2-yl)pyrimidin-4-yl]oxy]-5-fluoropyrimidin-4-amine
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Mus musculus
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
2.7.1.74
0.0000007
-
-
Mus musculus
2-[(6-[4-[(4-aminopyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]benzonitrile
2.7.1.74
0.000001
-
-
Mus musculus
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]benzonitrile
2.7.1.74
0.000001
-
-
Mus musculus
3-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-2-fluoropyrimidin-4-yl)oxy]-4-methoxybenzonitrile
2.7.1.74
0.000002
-
-
Mus musculus
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]-5-methoxybenzonitrile
2.7.1.74
0.000003
-
-
Mus musculus
2-([1-[6-(2-chlorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.000003
-
-
Mus musculus
2-([1-[6-(biphenyl-2-yloxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.000003
-
-
Mus musculus
2-(2-[1-[6-(1-benzothiophen-2-yl)pyrimidin-4-yl]piperidin-4-yl]ethoxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.000003
-
-
Mus musculus
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]pyrimidin-4-yl)oxy]-5-methoxybenzonitrile
2.7.1.74
0.000003
-
-
Mus musculus
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]pyrimidin-4-yl)oxy]benzonitrile
2.7.1.74
0.000004
-
-
Mus musculus
3-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]benzonitrile
2.7.1.74
0.000004
-
-
Mus musculus
5-fluoro-2-([1-[5-fluoro-6-(4-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
2.7.1.74
0.000005
-
-
Mus musculus
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-2-bromopyrimidin-4-yl)oxy]benzonitrile
2.7.1.74
0.000005
-
-
Mus musculus
3-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]-4-methoxybenzonitrile
2.7.1.74
0.000005
-
-
Mus musculus
5-fluoro-2-([1-[6-(2-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
2.7.1.74
0.000006
-
-
Mus musculus
5-fluoro-2-([1-[6-(2-fluorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
2.7.1.74
0.000009
-
-
Mus musculus
2-([1-[6-(4-chloro-2-methylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.000009
-
-
Mus musculus
5-fluoro-2-([1-[6-(2-methylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
2.7.1.74
0.00001
-
-
Mus musculus
2-([1-[6-(2-ethylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.00001
-
-
Mus musculus
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-2-methylpyrimidin-4-yl)oxy]benzonitrile
2.7.1.74
0.000013
-
-
Mus musculus
3-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]pyrimidin-4-yl)oxy]benzonitrile
2.7.1.74
0.000019
-
-
Mus musculus
2-([1-[6-(4-chlorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.000021
-
-
Mus musculus
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-methylpyrimidin-4-yl)oxy]benzonitrile
2.7.1.74
0.000021
-
-
Mus musculus
5-fluoro-2-([1-[6-(4-methylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
2.7.1.74
0.000022
-
-
Mus musculus
2-([1-[6-(3-chlorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.000023
-
-
Mus musculus
5-fluoro-2-([1-[6-(3-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
2.7.1.74
0.000033
-
-
Mus musculus
5-fluoro-2-([1-[6-(4-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
2.7.1.74
0.000034
-
-
Mus musculus
2-([1-[6-(1-benzothiophen-2-yl)pyrimidin-4-yl]piperidin-4-yl]methoxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.000038
-
-
Mus musculus
2-([1-[6-(1-benzothiophen-2-yl)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
2.7.1.74
0.000063
-
-
Mus musculus
2-([6-[4-(4-amino-2-oxopyrimidin-1(2H)-yl)piperidin-1-yl]-5-fluoropyrimidin-4-yl]oxy)benzonitrile
2.7.1.74
0.000095
-
-
Mus musculus
5-fluoro-2-[[1-(6-phenoxypyrimidin-4-yl)piperidin-4-yl]oxy]pyrimidin-4-amine
2.7.1.74
0.00012
-
-
Mus musculus
2'-deoxy-5-fluorocytidine
2.7.1.74
0.00051
-
-
Mus musculus
4-(1-benzothiophen-2-yl)-6-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]pyrimidine
2.7.1.74
0.00072
-
-
Mus musculus
2-[[6-(1-benzothiophen-2-yl)pyrimidin-4-yl]oxy]-5-fluoropyrimidin-4-amine
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.74
2'-deoxy-5-fluorocytidine
-
Mus musculus
2.7.1.74
2-(2-[1-[6-(1-benzothiophen-2-yl)pyrimidin-4-yl]piperidin-4-yl]ethoxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([1-[6-(1-benzothiophen-2-yl)pyrimidin-4-yl]piperidin-4-yl]methoxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([1-[6-(1-benzothiophen-2-yl)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([1-[6-(2-chlorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([1-[6-(2-ethylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([1-[6-(3-chlorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([1-[6-(4-chloro-2-methylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([1-[6-(4-chlorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([1-[6-(biphenyl-2-yloxy)pyrimidin-4-yl]piperidin-4-yl]oxy)-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
2-([6-[4-(4-amino-2-oxopyrimidin-1(2H)-yl)piperidin-1-yl]-5-fluoropyrimidin-4-yl]oxy)benzonitrile
-
Mus musculus
2.7.1.74
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-2-bromopyrimidin-4-yl)oxy]benzonitrile
-
Mus musculus
2.7.1.74
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-2-methylpyrimidin-4-yl)oxy]benzonitrile
-
Mus musculus
2.7.1.74
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]-5-methoxybenzonitrile
-
Mus musculus
2.7.1.74
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]benzonitrile
-
Mus musculus
2.7.1.74
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-methylpyrimidin-4-yl)oxy]benzonitrile
-
Mus musculus
2.7.1.74
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]pyrimidin-4-yl)oxy]-5-methoxybenzonitrile
-
Mus musculus
2.7.1.74
2-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]pyrimidin-4-yl)oxy]benzonitrile
-
Mus musculus
2.7.1.74
2-[(6-[4-[(4-aminopyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]benzonitrile
-
Mus musculus
2.7.1.74
2-[[6-(1-benzothiophen-2-yl)pyrimidin-4-yl]oxy]-5-fluoropyrimidin-4-amine
-
Mus musculus
2.7.1.74
3-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-2-fluoropyrimidin-4-yl)oxy]-4-methoxybenzonitrile
-
Mus musculus
2.7.1.74
3-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]-4-methoxybenzonitrile
-
Mus musculus
2.7.1.74
3-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]-5-fluoropyrimidin-4-yl)oxy]benzonitrile
-
Mus musculus
2.7.1.74
3-[(6-[4-[(4-amino-5-fluoropyrimidin-2-yl)oxy]piperidin-1-yl]pyrimidin-4-yl)oxy]benzonitrile
-
Mus musculus
2.7.1.74
4-(1-benzothiophen-2-yl)-6-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]pyrimidine
-
Mus musculus
2.7.1.74
5-fluoro-2-([1-[5-fluoro-6-(4-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
-
Mus musculus
2.7.1.74
5-fluoro-2-([1-[6-(2-fluorophenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
-
Mus musculus
2.7.1.74
5-fluoro-2-([1-[6-(2-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
-
Mus musculus
2.7.1.74
5-fluoro-2-([1-[6-(2-methylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
-
Mus musculus
2.7.1.74
5-fluoro-2-([1-[6-(3-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
-
Mus musculus
2.7.1.74
5-fluoro-2-([1-[6-(4-methoxyphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
-
Mus musculus
2.7.1.74
5-fluoro-2-([1-[6-(4-methylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxy)pyrimidin-4-amine
-
Mus musculus
2.7.1.74
5-fluoro-2-[[1-(6-phenoxypyrimidin-4-yl)piperidin-4-yl]oxy]pyrimidin-4-amine
-
Mus musculus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
spleen
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
702603
Mus musculus
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?