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Literature summary extracted from

  • Montgomery, J.I.; Toogood, P.L.; Hutchings, K.M.; Liu, J.; Narasimhan, L.; Braden, T.; Dermyer, M.R.; Kulynych, A.D.; Smith, Y.D.; Warmus, J.S.; Taylor, C.
    Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase (2009), Bioorg. Med. Chem. Lett., 19, 665-669.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.20 (4-[4-[(3-chlorobenzyl)oxy]-3-methylbenzoyl]piperazin-1-yl)(tetrahydrofuran-2-yl)methanone
-
 Haemophilus influenzae
6.1.1.20 (4-[4-[(3-chlorobenzyl)oxy]-3-methylbenzoyl]piperazin-1-yl)(tetrahydrofuran-2-yl)methanone
-
 Streptococcus pneumoniae
6.1.1.20 (4-[4-[2-(3-chlorophenyl)-2-hydroxyethyl]-3-methylbenzoyl]piperazin-1-yl)(tetrahydrofuran-2-yl)methanone
-
 Haemophilus influenzae
6.1.1.20 (4-[4-[2-(3-chlorophenyl)-2-hydroxyethyl]-3-methylbenzoyl]piperazin-1-yl)(tetrahydrofuran-2-yl)methanone
-
 Streptococcus pneumoniae
6.1.1.20 (5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-yl)acetic acid
-
 Haemophilus influenzae
6.1.1.20 (5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-yl)acetic acid
-
 Streptococcus pneumoniae
6.1.1.20 1-[4-[(3-chlorobenzyl)oxy]-3-methylbenzoyl]piperidine-4-carboxamide
-
 Haemophilus influenzae
6.1.1.20 1-[4-[(3-chlorobenzyl)oxy]-3-methylbenzoyl]piperidine-4-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 1-[4-[2-(3-chlorophenyl)ethyl]-3-methylbenzoyl]piperidine-4-carboxamide
-
 Haemophilus influenzae
6.1.1.20 1-[4-[2-(3-chlorophenyl)ethyl]-3-methylbenzoyl]piperidine-4-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 1-[[2-(3-chlorophenyl)-1-methyl-4-oxo-1,4-dihydroquinazolin-6-yl]carbonyl]piperidine-4-carboxamide
-
 Haemophilus influenzae
6.1.1.20 1-[[2-(3-chlorophenyl)-1-methyl-4-oxo-1,4-dihydroquinazolin-6-yl]carbonyl]piperidine-4-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 2-(5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-yl)acetamide
-
 Haemophilus influenzae
6.1.1.20 2-(5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-yl)acetamide
-
 Streptococcus pneumoniae
6.1.1.20 2-(5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-yl)ethanol
-
 Haemophilus influenzae
6.1.1.20 2-(5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-yl)ethanol
-
 Streptococcus pneumoniae
6.1.1.20 2-chloro-N-(3-chlorophenyl)-4-[(4-methyl-3-oxopiperazin-1-yl)carbonyl]benzenesulfonamide
-
 Haemophilus influenzae
6.1.1.20 2-chloro-N-(3-chlorophenyl)-4-[(4-methyl-3-oxopiperazin-1-yl)carbonyl]benzenesulfonamide
-
 Streptococcus pneumoniae
6.1.1.20 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazole
-
 Haemophilus influenzae
6.1.1.20 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazole
-
 Streptococcus pneumoniae
6.1.1.20 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-(methylsulfanyl)-1,3,4-oxadiazole
-
 Haemophilus influenzae
6.1.1.20 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-(methylsulfanyl)-1,3,4-oxadiazole
-
 Streptococcus pneumoniae
6.1.1.20 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-(methylsulfinyl)-1,3,4-oxadiazole
-
 Haemophilus influenzae
6.1.1.20 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-(methylsulfinyl)-1,3,4-oxadiazole
-
 Streptococcus pneumoniae
6.1.1.20 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-(methylsulfonyl)-1,3,4-oxadiazole
-
 Haemophilus influenzae
6.1.1.20 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-(methylsulfonyl)-1,3,4-oxadiazole
-
 Streptococcus pneumoniae
6.1.1.20 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-ethyl-1,3,4-oxadiazole
-
 Haemophilus influenzae
6.1.1.20 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-ethyl-1,3,4-oxadiazole
-
 Streptococcus pneumoniae
6.1.1.20 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-methyl-1,3,4-oxadiazole
-
 Haemophilus influenzae
6.1.1.20 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-methyl-1,3,4-oxadiazole
-
 Streptococcus pneumoniae
6.1.1.20 3-chloro-4-[(3-chlorobenzyl)oxy]-N-(1-hydroxypropan-2-yl)benzamide
-
 Haemophilus influenzae
6.1.1.20 3-chloro-4-[(3-chlorobenzyl)oxy]-N-(1-hydroxypropan-2-yl)benzamide
-
 Streptococcus pneumoniae
6.1.1.20 3-chloro-4-[(3-chlorobenzyl)oxy]-N-(4-hydroxybutyl)benzamide
-
 Haemophilus influenzae
6.1.1.20 3-chloro-4-[(3-chlorobenzyl)oxy]-N-(4-hydroxybutyl)benzamide
-
 Streptococcus pneumoniae
6.1.1.20 3-chloro-4-[(3-chlorobenzyl)oxy]-N-(cyclopropylmethyl)benzamide
-
 Haemophilus influenzae
6.1.1.20 3-chloro-4-[(3-chlorobenzyl)oxy]-N-(cyclopropylmethyl)benzamide
-
 Streptococcus pneumoniae
6.1.1.20 3-chloro-4-[(3-chlorobenzyl)oxy]-N-[2-(ethylamino)ethyl]-N-methylbenzenesulfonamide
-
 Haemophilus influenzae
6.1.1.20 3-chloro-4-[(3-chlorobenzyl)oxy]-N-[2-(ethylamino)ethyl]-N-methylbenzenesulfonamide
-
 Streptococcus pneumoniae
6.1.1.20 3-chloro-4-[(3-chlorobenzyl)oxy]-N-[2-(morpholin-4-yl)ethyl]benzamide
-
 Haemophilus influenzae
6.1.1.20 3-chloro-4-[(3-chlorobenzyl)oxy]-N-[2-(morpholin-4-yl)ethyl]benzamide
-
 Streptococcus pneumoniae
6.1.1.20 3-chloro-N-[2-methyl-4-[(4-methyl-3-oxopiperazin-1-yl)carbonyl]phenyl]benzenesulfonamide
-
 Haemophilus influenzae
6.1.1.20 3-chloro-N-[2-methyl-4-[(4-methyl-3-oxopiperazin-1-yl)carbonyl]phenyl]benzenesulfonamide
-
 Streptococcus pneumoniae
6.1.1.20 4-(3-chloro-4-[[(3-chlorophenyl)sulfinyl]methyl]benzoyl)-1-methylpiperazin-2-one
-
 Haemophilus influenzae
6.1.1.20 4-(3-chloro-4-[[(3-chlorophenyl)sulfinyl]methyl]benzoyl)-1-methylpiperazin-2-one
-
 Streptococcus pneumoniae
6.1.1.20 4-(3-chloro-4-[[(3-chlorophenyl)sulfonyl]methyl]benzoyl)-1-methylpiperazin-2-one
-
 Haemophilus influenzae
6.1.1.20 4-(3-chloro-4-[[(3-chlorophenyl)sulfonyl]methyl]benzoyl)-1-methylpiperazin-2-one
-
 Streptococcus pneumoniae
6.1.1.20 4-chloro-5-[(3-chlorobenzyl)oxy]-2-(1,3,4-oxadiazol-2-yl)pyridine
-
 Haemophilus influenzae
6.1.1.20 4-chloro-5-[(3-chlorobenzyl)oxy]-2-(1,3,4-oxadiazol-2-yl)pyridine
-
 Streptococcus pneumoniae
6.1.1.20 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(1-ethyl-1H-pyrazol-5-yl)pyridine-2-carboxamide
-
 Haemophilus influenzae
6.1.1.20 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(1-ethyl-1H-pyrazol-5-yl)pyridine-2-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(1-hydroxypropan-2-yl)pyridine-2-carboxamide
-
 Haemophilus influenzae
6.1.1.20 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(1-hydroxypropan-2-yl)pyridine-2-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(4-hydroxybutyl)pyridine-2-carboxamide
-
 Haemophilus influenzae
6.1.1.20 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(4-hydroxybutyl)pyridine-2-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(4-hydroxycyclohexyl)pyridine-2-carboxamide
-
 Haemophilus influenzae
6.1.1.20 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(4-hydroxycyclohexyl)pyridine-2-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(cyclopropylmethyl)pyridine-2-carboxamide
-
 Haemophilus influenzae
6.1.1.20 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(cyclopropylmethyl)pyridine-2-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 4-chloro-5-[(3-chlorobenzyl)oxy]-N-[2-(morpholin-4-yl)ethyl]pyridine-2-carboxamide
-
 Haemophilus influenzae
6.1.1.20 4-chloro-5-[(3-chlorobenzyl)oxy]-N-[2-(morpholin-4-yl)ethyl]pyridine-2-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 4-[3-chloro-4-[(3-chlorobenzyl)oxy]benzoyl]-1-methylpiperazin-2-one
-
 Haemophilus influenzae
6.1.1.20 4-[3-chloro-4-[(3-chlorobenzyl)oxy]benzoyl]-1-methylpiperazin-2-one
-
 Streptococcus pneumoniae
6.1.1.20 5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-amine
-
 Haemophilus influenzae
6.1.1.20 5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-amine
-
 Streptococcus pneumoniae
6.1.1.20 5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazole-2-carboxamide
-
 Haemophilus influenzae
6.1.1.20 5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazole-2-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 5-[4-chloro-5-[(3-chlorobenzyl)oxy]pyridin-2-yl]-1,3,4-oxadiazol-2-amine
-
 Haemophilus influenzae
6.1.1.20 5-[4-chloro-5-[(3-chlorobenzyl)oxy]pyridin-2-yl]-1,3,4-oxadiazol-2-amine
-
 Streptococcus pneumoniae
6.1.1.20 5-[4-chloro-5-[(3-chlorobenzyl)oxy]pyridin-2-yl]-1,3,4-oxadiazole-2-carboxamide
-
 Haemophilus influenzae
6.1.1.20 5-[4-chloro-5-[(3-chlorobenzyl)oxy]pyridin-2-yl]-1,3,4-oxadiazole-2-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 methyl 3-chloro-4-[(3,4-difluorobenzyl)oxy]benzoate
-
 Haemophilus influenzae
6.1.1.20 methyl 3-chloro-4-[(3,4-difluorobenzyl)oxy]benzoate
-
 Streptococcus pneumoniae
6.1.1.20 methyl 3-chloro-4-[(3-chlorobenzyl)oxy]benzoate
-
 Haemophilus influenzae
6.1.1.20 methyl 3-chloro-4-[(3-chlorobenzyl)oxy]benzoate
-
 Streptococcus pneumoniae
6.1.1.20 methyl 3-chloro-4-[(3-fluorobenzyl)oxy]benzoate
-
 Haemophilus influenzae
6.1.1.20 methyl 3-chloro-4-[(3-fluorobenzyl)oxy]benzoate
-
 Streptococcus pneumoniae
6.1.1.20 methyl 4-[(1R,2R)-2-(3-chlorophenyl)-1,2-dihydroxyethyl]-3-methylbenzoate
-
 Haemophilus influenzae
6.1.1.20 methyl 4-[(1R,2R)-2-(3-chlorophenyl)-1,2-dihydroxyethyl]-3-methylbenzoate
-
 Streptococcus pneumoniae
6.1.1.20 methyl 4-[(1S,2S)-2-(3-chlorophenyl)-1,2-dihydroxyethyl]-3-methylbenzoate
-
 Haemophilus influenzae
6.1.1.20 methyl 4-[(1S,2S)-2-(3-chlorophenyl)-1,2-dihydroxyethyl]-3-methylbenzoate
-
 Streptococcus pneumoniae
6.1.1.20 methyl 4-[(3-chlorobenzoyl)amino]-3-methylbenzoate
-
 Haemophilus influenzae
6.1.1.20 methyl 4-[(3-chlorobenzoyl)amino]-3-methylbenzoate
-
 Streptococcus pneumoniae
6.1.1.20 methyl 4-[(3-chlorobenzyl)(methyl)amino]-3-methylbenzoate
-
 Haemophilus influenzae
6.1.1.20 methyl 4-[(3-chlorobenzyl)(methyl)amino]-3-methylbenzoate
-
 Streptococcus pneumoniae
6.1.1.20 methyl 4-[(3-chlorobenzyl)amino]-3-methylbenzoate
-
 Haemophilus influenzae
6.1.1.20 methyl 4-[(3-chlorobenzyl)amino]-3-methylbenzoate
-
 Streptococcus pneumoniae
6.1.1.20 methyl 4-[(3-chlorobenzyl)oxy]-3-methylbenzoate
-
 Haemophilus influenzae
6.1.1.20 methyl 4-[(3-chlorobenzyl)oxy]-3-methylbenzoate
-
 Streptococcus pneumoniae
6.1.1.20 methyl 4-[(3-chlorobenzyl)oxy]benzoate
-
 Haemophilus influenzae
6.1.1.20 methyl 4-[(3-chlorobenzyl)oxy]benzoate
-
 Streptococcus pneumoniae
6.1.1.20 methyl 4-[(3-chlorophenyl)carbamoyl]benzoate
-
 Haemophilus influenzae
6.1.1.20 methyl 4-[(3-chlorophenyl)carbamoyl]benzoate
-
 Streptococcus pneumoniae
6.1.1.20 methyl 4-[(E)-2-(3-chlorophenyl)ethenyl]-3-methylbenzoate
-
 Haemophilus influenzae
6.1.1.20 methyl 4-[(E)-2-(3-chlorophenyl)ethenyl]-3-methylbenzoate
-
 Streptococcus pneumoniae
6.1.1.20 methyl 4-[[(3-chlorophenyl)(methyl)amino]methyl]benzoate
-
 Haemophilus influenzae
6.1.1.20 methyl 4-[[(3-chlorophenyl)(methyl)amino]methyl]benzoate
-
 Streptococcus pneumoniae
6.1.1.20 methyl 4-[[(3-chlorophenyl)amino]methyl]benzoate
-
 Haemophilus influenzae
6.1.1.20 methyl 4-[[(3-chlorophenyl)amino]methyl]benzoate
-
 Streptococcus pneumoniae
6.1.1.20 N-(1-[3-chloro-4-[(4-chlorobenzyl)oxy]benzyl]pyrrolidin-3-yl)acetamide
-
 Haemophilus influenzae
6.1.1.20 N-(1-[3-chloro-4-[(4-chlorobenzyl)oxy]benzyl]pyrrolidin-3-yl)acetamide
-
 Streptococcus pneumoniae
6.1.1.20 N-(5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-yl)acetamide
-
 Haemophilus influenzae
6.1.1.20 N-(5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-yl)acetamide
-
 Streptococcus pneumoniae
6.1.1.20 [3-chloro-4-[(3-chlorobenzyl)oxy]phenyl](4-methylpiperazin-1-yl)methanone
-
 Haemophilus influenzae
6.1.1.20 [3-chloro-4-[(3-chlorobenzyl)oxy]phenyl](4-methylpiperazin-1-yl)methanone
-
 Streptococcus pneumoniae
6.1.1.20 [3-chloro-4-[(3-chlorophenoxy)methyl]phenyl](4-methylpiperazin-1-yl)methanone
-
 Haemophilus influenzae
6.1.1.20 [3-chloro-4-[(3-chlorophenoxy)methyl]phenyl](4-methylpiperazin-1-yl)methanone
-
 Streptococcus pneumoniae
6.1.1.20 [4-([3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]sulfonyl)piperazin-1-yl](4-methylphenyl)methanone
-
 Haemophilus influenzae
6.1.1.20 [4-([3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]sulfonyl)piperazin-1-yl](4-methylphenyl)methanone
-
 Streptococcus pneumoniae
6.1.1.20 [4-[1-(3-chlorophenyl)-2-hydroxyethyl]-3-methylphenyl](4-methylpiperazin-1-yl)methanone
-
 Haemophilus influenzae
6.1.1.20 [4-[1-(3-chlorophenyl)-2-hydroxyethyl]-3-methylphenyl](4-methylpiperazin-1-yl)methanone
-
 Streptococcus pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.20 Haemophilus influenzae
-
-
-
6.1.1.20 Streptococcus pneumoniae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.20 ATP + L-phenylalanine + tRNAPhe
-
 Haemophilus influenzae AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
 ?
6.1.1.20 ATP + L-phenylalanine + tRNAPhe
-
 Streptococcus pneumoniae AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.20 Phenylalanyl-tRNA synthetase
-
 Haemophilus influenzae
6.1.1.20 Phenylalanyl-tRNA synthetase
-
 Streptococcus pneumoniae
6.1.1.20 PheRS
-
 Haemophilus influenzae
6.1.1.20 PheRS
-
 Streptococcus pneumoniae

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.20 ATP
-
 Haemophilus influenzae
6.1.1.20 ATP
-
 Streptococcus pneumoniae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.1.1.20 0.0000013
-
 N-(5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-yl)acetamide
-
 Haemophilus influenzae
6.1.1.20 0.0000015
-
 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(4-hydroxycyclohexyl)pyridine-2-carboxamide
-
 Haemophilus influenzae
6.1.1.20 0.0000015
-
 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-(methylsulfinyl)-1,3,4-oxadiazole
-
 Haemophilus influenzae
6.1.1.20 0.0000017
-
 2-(5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-yl)acetamide
-
 Haemophilus influenzae
6.1.1.20 0.0000019
-
 3-chloro-4-[(3-chlorobenzyl)oxy]-N-[2-(ethylamino)ethyl]-N-methylbenzenesulfonamide
-
 Haemophilus influenzae
6.1.1.20 0.0000019
-
 [4-([3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]sulfonyl)piperazin-1-yl](4-methylphenyl)methanone
-
 Haemophilus influenzae
6.1.1.20 0.0000021
-
 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-(methylsulfonyl)-1,3,4-oxadiazole
-
 Haemophilus influenzae
6.1.1.20 0.0000023
-
 5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-amine
-
 Haemophilus influenzae
6.1.1.20 0.0000026
-
 5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazole-2-carboxamide
-
 Haemophilus influenzae
6.1.1.20 0.0000027
-
 5-[4-chloro-5-[(3-chlorobenzyl)oxy]pyridin-2-yl]-1,3,4-oxadiazole-2-carboxamide
-
 Haemophilus influenzae
6.1.1.20 0.0000031
-
 2-(5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-yl)ethanol
-
 Haemophilus influenzae
6.1.1.20 0.0000055
-
 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-(methylsulfanyl)-1,3,4-oxadiazole
-
 Haemophilus influenzae
6.1.1.20 0.0000066
-
 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-methyl-1,3,4-oxadiazole
-
 Haemophilus influenzae
6.1.1.20 0.000008
-
 4-chloro-5-[(3-chlorobenzyl)oxy]-N-[2-(morpholin-4-yl)ethyl]pyridine-2-carboxamide
-
 Haemophilus influenzae
6.1.1.20 0.0000087
-
 methyl 3-chloro-4-[(3,4-difluorobenzyl)oxy]benzoate
-
 Haemophilus influenzae
6.1.1.20 0.000011
-
 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazole
-
 Haemophilus influenzae
6.1.1.20 0.000011
-
 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-ethyl-1,3,4-oxadiazole
-
 Haemophilus influenzae
6.1.1.20 0.000011
-
 (5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-yl)acetic acid
-
 Haemophilus influenzae
6.1.1.20 0.000012
-
 [4-([3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]sulfonyl)piperazin-1-yl](4-methylphenyl)methanone
-
 Streptococcus pneumoniae
6.1.1.20 0.000012
-
 4-chloro-5-[(3-chlorobenzyl)oxy]-2-(1,3,4-oxadiazol-2-yl)pyridine
-
 Haemophilus influenzae
6.1.1.20 0.000014
-
 3-chloro-4-[(3-chlorobenzyl)oxy]-N-[2-(morpholin-4-yl)ethyl]benzamide
-
 Haemophilus influenzae
6.1.1.20 0.000016
-
 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(4-hydroxybutyl)pyridine-2-carboxamide
-
 Haemophilus influenzae
6.1.1.20 0.000017
-
 methyl 3-chloro-4-[(3-chlorobenzyl)oxy]benzoate
-
 Haemophilus influenzae
6.1.1.20 0.000022
-
 3-chloro-4-[(3-chlorobenzyl)oxy]-N-(4-hydroxybutyl)benzamide
-
 Haemophilus influenzae
6.1.1.20 0.000024
-
 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(1-ethyl-1H-pyrazol-5-yl)pyridine-2-carboxamide
-
 Haemophilus influenzae
6.1.1.20 0.000028
-
 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(4-hydroxycyclohexyl)pyridine-2-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 0.000028
-
 N-(5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-yl)acetamide
-
 Streptococcus pneumoniae
6.1.1.20 0.000029
-
 3-chloro-4-[(3-chlorobenzyl)oxy]-N-(1-hydroxypropan-2-yl)benzamide
-
 Haemophilus influenzae
6.1.1.20 0.00003
-
 methyl 3-chloro-4-[(3-fluorobenzyl)oxy]benzoate
-
 Haemophilus influenzae
6.1.1.20 0.00003
-
 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(cyclopropylmethyl)pyridine-2-carboxamide
-
 Haemophilus influenzae
6.1.1.20 0.000034
-
 methyl 4-[(3-chlorobenzyl)oxy]-3-methylbenzoate
-
 Haemophilus influenzae
6.1.1.20 0.000034
-
 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(4-hydroxybutyl)pyridine-2-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 0.000034
-
 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(1-ethyl-1H-pyrazol-5-yl)pyridine-2-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 0.000036
-
 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-(methylsulfinyl)-1,3,4-oxadiazole
-
 Streptococcus pneumoniae
6.1.1.20 0.000038
-
 4-[3-chloro-4-[(3-chlorobenzyl)oxy]benzoyl]-1-methylpiperazin-2-one
-
 Haemophilus influenzae
6.1.1.20 0.000042
-
 5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-amine
-
 Streptococcus pneumoniae
6.1.1.20 0.000043
-
 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(1-hydroxypropan-2-yl)pyridine-2-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 0.000046
-
 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(1-hydroxypropan-2-yl)pyridine-2-carboxamide
-
 Haemophilus influenzae
6.1.1.20 0.00005
-
 4-chloro-5-[(3-chlorobenzyl)oxy]-N-(cyclopropylmethyl)pyridine-2-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 0.00005
-
 5-[4-chloro-5-[(3-chlorobenzyl)oxy]pyridin-2-yl]-1,3,4-oxadiazol-2-amine
-
 Streptococcus pneumoniae
6.1.1.20 0.000053
-
 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-(methylsulfonyl)-1,3,4-oxadiazole
-
 Streptococcus pneumoniae
6.1.1.20 0.000057
-
 3-chloro-4-[(3-chlorobenzyl)oxy]-N-(cyclopropylmethyl)benzamide
-
 Haemophilus influenzae
6.1.1.20 0.00006
-
 5-[4-chloro-5-[(3-chlorobenzyl)oxy]pyridin-2-yl]-1,3,4-oxadiazole-2-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 0.000065
-
 4-chloro-5-[(3-chlorobenzyl)oxy]-N-[2-(morpholin-4-yl)ethyl]pyridine-2-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 0.000067
-
 (4-[4-[(3-chlorobenzyl)oxy]-3-methylbenzoyl]piperazin-1-yl)(tetrahydrofuran-2-yl)methanone
-
 Haemophilus influenzae
6.1.1.20 0.000076
-
 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-ethyl-1,3,4-oxadiazole
-
 Streptococcus pneumoniae
6.1.1.20 0.000079
-
 3-chloro-4-[(3-chlorobenzyl)oxy]-N-[2-(ethylamino)ethyl]-N-methylbenzenesulfonamide
-
 Streptococcus pneumoniae
6.1.1.20 0.000081
-
 5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazole-2-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 0.000081
-
 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-(methylsulfanyl)-1,3,4-oxadiazole
-
 Streptococcus pneumoniae
6.1.1.20 0.000087
-
 2-(5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-yl)ethanol
-
 Streptococcus pneumoniae
6.1.1.20 0.000091
-
 methyl 3-chloro-4-[(3-chlorobenzyl)oxy]benzoate
-
 Streptococcus pneumoniae
6.1.1.20 0.000095
-
 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-5-methyl-1,3,4-oxadiazole
-
 Streptococcus pneumoniae
6.1.1.20 0.000097
-
 methyl 4-[(3-chlorobenzyl)oxy]-3-methylbenzoate
-
 Streptococcus pneumoniae
6.1.1.20 0.000097
-
 4-chloro-5-[(3-chlorobenzyl)oxy]-2-(1,3,4-oxadiazol-2-yl)pyridine
-
 Streptococcus pneumoniae
6.1.1.20 0.00011
-
 (5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-yl)acetic acid
-
 Streptococcus pneumoniae
6.1.1.20 0.00012
-
 methyl 3-chloro-4-[(3,4-difluorobenzyl)oxy]benzoate
-
 Streptococcus pneumoniae
6.1.1.20 0.000126
-
 2-(5-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazol-2-yl)acetamide
-
 Streptococcus pneumoniae
6.1.1.20 0.00013
-
 methyl 4-[(E)-2-(3-chlorophenyl)ethenyl]-3-methylbenzoate
-
 Haemophilus influenzae
6.1.1.20 0.00015
-
 [3-chloro-4-[(3-chlorobenzyl)oxy]phenyl](4-methylpiperazin-1-yl)methanone
-
 Haemophilus influenzae
6.1.1.20 0.00015
-
 1-[4-[(3-chlorobenzyl)oxy]-3-methylbenzoyl]piperidine-4-carboxamide
-
 Haemophilus influenzae
6.1.1.20 0.000156
-
 2-[3-chloro-4-[(3-chlorobenzyl)oxy]phenyl]-1,3,4-oxadiazole
-
 Streptococcus pneumoniae
6.1.1.20 0.00016
-
 methyl 3-chloro-4-[(3-fluorobenzyl)oxy]benzoate
-
 Streptococcus pneumoniae
6.1.1.20 0.00017
-
 methyl 4-[(3-chlorobenzyl)(methyl)amino]-3-methylbenzoate
-
 Haemophilus influenzae
6.1.1.20 0.00024
-
 N-(1-[3-chloro-4-[(4-chlorobenzyl)oxy]benzyl]pyrrolidin-3-yl)acetamide
-
 Haemophilus influenzae
6.1.1.20 0.000254
-
 3-chloro-4-[(3-chlorobenzyl)oxy]-N-(4-hydroxybutyl)benzamide
-
 Streptococcus pneumoniae
6.1.1.20 0.00028
-
 (4-[4-[2-(3-chlorophenyl)-2-hydroxyethyl]-3-methylbenzoyl]piperazin-1-yl)(tetrahydrofuran-2-yl)methanone
-
 Haemophilus influenzae
6.1.1.20 0.00036
-
 1-[4-[2-(3-chlorophenyl)ethyl]-3-methylbenzoyl]piperidine-4-carboxamide
-
 Haemophilus influenzae
6.1.1.20 0.000393
-
 3-chloro-4-[(3-chlorobenzyl)oxy]-N-(cyclopropylmethyl)benzamide
-
 Streptococcus pneumoniae
6.1.1.20 0.000438
-
 3-chloro-4-[(3-chlorobenzyl)oxy]-N-[2-(morpholin-4-yl)ethyl]benzamide
-
 Streptococcus pneumoniae
6.1.1.20 0.000483
-
 3-chloro-4-[(3-chlorobenzyl)oxy]-N-(1-hydroxypropan-2-yl)benzamide
-
 Streptococcus pneumoniae
6.1.1.20 0.00084
-
 [3-chloro-4-[(3-chlorophenoxy)methyl]phenyl](4-methylpiperazin-1-yl)methanone
-
 Haemophilus influenzae
6.1.1.20 0.0013
-
 4-[3-chloro-4-[(3-chlorobenzyl)oxy]benzoyl]-1-methylpiperazin-2-one
-
 Streptococcus pneumoniae
6.1.1.20 0.002
-
 methyl 4-[(E)-2-(3-chlorophenyl)ethenyl]-3-methylbenzoate
-
 Streptococcus pneumoniae
6.1.1.20 0.0022
-
 N-(1-[3-chloro-4-[(4-chlorobenzyl)oxy]benzyl]pyrrolidin-3-yl)acetamide
-
 Streptococcus pneumoniae
6.1.1.20 0.0023
-
 [3-chloro-4-[(3-chlorobenzyl)oxy]phenyl](4-methylpiperazin-1-yl)methanone
-
 Streptococcus pneumoniae
6.1.1.20 0.0024
-
 4-(3-chloro-4-[[(3-chlorophenyl)sulfinyl]methyl]benzoyl)-1-methylpiperazin-2-one
-
 Haemophilus influenzae
6.1.1.20 0.0031
-
 methyl 4-[(3-chlorobenzyl)oxy]benzoate
-
 Haemophilus influenzae
6.1.1.20 0.0035
-
 methyl 4-[(3-chlorobenzyl)amino]-3-methylbenzoate
-
 Haemophilus influenzae
6.1.1.20 0.0035
-
 methyl 4-[(3-chlorobenzyl)(methyl)amino]-3-methylbenzoate
-
 Streptococcus pneumoniae
6.1.1.20 0.0037
-
 (4-[4-[(3-chlorobenzyl)oxy]-3-methylbenzoyl]piperazin-1-yl)(tetrahydrofuran-2-yl)methanone
-
 Streptococcus pneumoniae
6.1.1.20 0.0061
-
 methyl 4-[(3-chlorobenzyl)amino]-3-methylbenzoate
-
 Streptococcus pneumoniae
6.1.1.20 0.0064
-
 [4-[1-(3-chlorophenyl)-2-hydroxyethyl]-3-methylphenyl](4-methylpiperazin-1-yl)methanone larger than 0.064 Streptococcus pneumoniae
6.1.1.20 0.0065
-
 methyl 4-[(1S,2S)-2-(3-chlorophenyl)-1,2-dihydroxyethyl]-3-methylbenzoate
-
 Haemophilus influenzae
6.1.1.20 0.011
-
 (4-[4-[2-(3-chlorophenyl)-2-hydroxyethyl]-3-methylbenzoyl]piperazin-1-yl)(tetrahydrofuran-2-yl)methanone
-
 Streptococcus pneumoniae
6.1.1.20 0.012
-
 methyl 4-[(3-chlorobenzyl)oxy]benzoate
-
 Streptococcus pneumoniae
6.1.1.20 0.023
-
 4-(3-chloro-4-[[(3-chlorophenyl)sulfinyl]methyl]benzoyl)-1-methylpiperazin-2-one
-
 Streptococcus pneumoniae
6.1.1.20 0.046
-
 1-[4-[2-(3-chlorophenyl)ethyl]-3-methylbenzoyl]piperidine-4-carboxamide
-
 Streptococcus pneumoniae
6.1.1.20 0.057
-
 methyl 4-[[(3-chlorophenyl)amino]methyl]benzoate
-
 Haemophilus influenzae
6.1.1.20 0.064
-
 methyl 4-[[(3-chlorophenyl)amino]methyl]benzoate larger than 0.064 Streptococcus pneumoniae
6.1.1.20 0.064
-
 methyl 4-[[(3-chlorophenyl)(methyl)amino]methyl]benzoate larger than 0.064 Haemophilus influenzae
6.1.1.20 0.064
-
 methyl 4-[[(3-chlorophenyl)(methyl)amino]methyl]benzoate larger than 0.064 Streptococcus pneumoniae
6.1.1.20 0.064
-
 methyl 4-[(3-chlorobenzoyl)amino]-3-methylbenzoate larger than 0.064 Haemophilus influenzae
6.1.1.20 0.064
-
 methyl 4-[(3-chlorobenzoyl)amino]-3-methylbenzoate larger than 0.064 Streptococcus pneumoniae
6.1.1.20 0.064
-
 methyl 4-[(3-chlorophenyl)carbamoyl]benzoate larger than 0.064 Haemophilus influenzae
6.1.1.20 0.064
-
 methyl 4-[(3-chlorophenyl)carbamoyl]benzoate larger than 0.064 Streptococcus pneumoniae
6.1.1.20 0.064
-
 methyl 4-[(1S,2S)-2-(3-chlorophenyl)-1,2-dihydroxyethyl]-3-methylbenzoate larger than 0.064 Streptococcus pneumoniae
6.1.1.20 0.064
-
 methyl 4-[(1R,2R)-2-(3-chlorophenyl)-1,2-dihydroxyethyl]-3-methylbenzoate larger than 0.064 Haemophilus influenzae
6.1.1.20 0.064
-
 methyl 4-[(1R,2R)-2-(3-chlorophenyl)-1,2-dihydroxyethyl]-3-methylbenzoate larger than 0.064 Streptococcus pneumoniae
6.1.1.20 0.064
-
 [4-[1-(3-chlorophenyl)-2-hydroxyethyl]-3-methylphenyl](4-methylpiperazin-1-yl)methanone larger than 0.064 Haemophilus influenzae
6.1.1.20 0.064
-
 4-(3-chloro-4-[[(3-chlorophenyl)sulfonyl]methyl]benzoyl)-1-methylpiperazin-2-one larger than 0.064 Haemophilus influenzae
6.1.1.20 0.064
-
 4-(3-chloro-4-[[(3-chlorophenyl)sulfonyl]methyl]benzoyl)-1-methylpiperazin-2-one larger than 0.064 Streptococcus pneumoniae
6.1.1.20 0.064
-
 3-chloro-N-[2-methyl-4-[(4-methyl-3-oxopiperazin-1-yl)carbonyl]phenyl]benzenesulfonamide larger than 0.064 Haemophilus influenzae
6.1.1.20 0.064
-
 3-chloro-N-[2-methyl-4-[(4-methyl-3-oxopiperazin-1-yl)carbonyl]phenyl]benzenesulfonamide larger than 0.064 Streptococcus pneumoniae
6.1.1.20 0.064
-
 2-chloro-N-(3-chlorophenyl)-4-[(4-methyl-3-oxopiperazin-1-yl)carbonyl]benzenesulfonamide larger than 0.064 Haemophilus influenzae
6.1.1.20 0.064
-
 2-chloro-N-(3-chlorophenyl)-4-[(4-methyl-3-oxopiperazin-1-yl)carbonyl]benzenesulfonamide larger than 0.064 Streptococcus pneumoniae
6.1.1.20 0.064
-
 1-[[2-(3-chlorophenyl)-1-methyl-4-oxo-1,4-dihydroquinazolin-6-yl]carbonyl]piperidine-4-carboxamide larger than 0.064 Haemophilus influenzae
6.1.1.20 0.064
-
 1-[[2-(3-chlorophenyl)-1-methyl-4-oxo-1,4-dihydroquinazolin-6-yl]carbonyl]piperidine-4-carboxamide larger than 0.064 Streptococcus pneumoniae