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Literature summary extracted from

  • Todoroki, Y.; Aoyama, H.; Hiramatsu, S.; Shirakura, M.; Nimitkeatkai, H.; Kondo, S.; Ueno, K.; Mizutani, M.; Hirai, N.
    Enlarged analogues of uniconazole, new azole containing inhibitors of ABA 8-hydroxylase CYP707A (2009), Bioorg. Med. Chem. Lett., 19, 5782-5786.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.137 a truncated CYP707A3 (707A3d28), which lacks the putative membrane-spanning segment of the N-terminus (residues 3–28) coexpressed in Escherichia coli strain BL21 with Arabidopsis P450 reductase Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.137 (1E)-1-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol 0.01 mM, inhibits by 100% Arabidopsis thaliana
1.14.14.137 (1E)-1-[4-(4-heptyl-1H-1,2,3-triazol-1-yl)phenyl]-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol 0.01 mM, inhibits by 96% Arabidopsis thaliana
1.14.14.137 (1E)-1-[4-[4-(1-hydroxybutyl)-1H-1,2,3-triazol-1-yl]phenyl]-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol 0.01 mM, inhibits by 92% Arabidopsis thaliana
1.14.14.137 (1E)-1-[4-[4-(1-hydroxyethyl)-1H-1,2,3-triazol-1-yl]phenyl]-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol 0.01 mM, inhibits by 77% Arabidopsis thaliana
1.14.14.137 (1E)-1-[4-[4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl]phenyl]-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol 0.01 mM, inhibits by 83% Arabidopsis thaliana
1.14.14.137 (1E)-4,4-dimethyl-1-[4-(4-nonyl-1H-1,2,3-triazol-1-yl)phenyl]-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol 0.01 mM, inhibits by 100% Arabidopsis thaliana
1.14.14.137 (1E)-4,4-dimethyl-1-[4-(4-pentadecyl-1H-1,2,3-triazol-1-yl)phenyl]-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol 0.01 mM, inhibits by 54% Arabidopsis thaliana
1.14.14.137 (1E)-4,4-dimethyl-1-[4-(4-propyl-1H-1,2,3-triazol-1-yl)phenyl]-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-ol 0.01 mM, inhibits by 92% Arabidopsis thaliana
1.14.14.137 (1E)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)-1-[4-(4-tridecyl-1H-1,2,3-triazol-1-yl)phenyl]pent-1-en-3-ol 0.01 mM, inhibits by 95% Arabidopsis thaliana
1.14.14.137 (1E)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)-1-[4-(4-undecyl-1H-1,2,3-triazol-1-yl)phenyl]pent-1-en-3-ol 0.01 mM, inhibits by 100% Arabidopsis thaliana
1.14.14.137 4-(1-[4-[(1E)-3-hydroxy-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-1-yl]phenyl]-1H-1,2,3-triazol-4-yl)butanoic acid 0.01 mM, inhibits by 63% Arabidopsis thaliana
1.14.14.137 S-UNI inhibits by 100% Arabidopsis thaliana

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.14.137 0.0034
-
 (+)-abscisic acid
-
 Arabidopsis thaliana

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.137 Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.137 (+)-abscisic acid + [reduced NADPH-hemoprotein reductase] + O2
-
 Arabidopsis thaliana 8'-hydroxyabscisate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.137 ABA 8'-hydroxylase
-
 Arabidopsis thaliana
1.14.14.137 abscisic acid 8'-hydroxylase
-
 Arabidopsis thaliana
1.14.14.137 CYP707A3
-
 Arabidopsis thaliana

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.14.137 0.00001
-
 S-UNI
-
 Arabidopsis thaliana
1.14.14.137 0.000195
-
 4-(1-[4-[(1E)-3-hydroxy-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pent-1-en-1-yl]phenyl]-1H-1,2,3-triazol-4-yl)butanoic acid
-
 Arabidopsis thaliana