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Literature summary extracted from

  • Innocenti, A.; Hilvo, M.; Parkkila, S.; Scozzafava, A.; Supuran, C.
    Carbonic anhydrase inhibitors: The membrane-associated isoform XV is highly inhibited by inorganic anions (2009), Bioorg. Med. Chem. Lett., 19, 1155-1158.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.1 azide shows low micromolar inhibition against CA XV Mus musculus
4.2.1.1 bicarbonate shows low micromolar inhibition against CA XV Mus musculus
4.2.1.1 bromide
-
 Mus musculus
4.2.1.1 Carbonate
-
 Mus musculus
4.2.1.1 chloride
-
 Mus musculus
4.2.1.1 cyanide shows low micromolar inhibition against CA XV Mus musculus
4.2.1.1 fluoride
-
 Mus musculus
4.2.1.1 hydrogen sulfide shows low micromolar inhibition against CA XV Mus musculus
4.2.1.1 hydrogen sulfite shows low micromolar inhibition against CA XV Mus musculus
4.2.1.1 Iodide
-
 Mus musculus
4.2.1.1 additional information isoform CA XV is not inhibited by tetrafluoroborate Mus musculus
4.2.1.1 nitrate
-
 Mus musculus
4.2.1.1 nitrite
-
 Mus musculus
4.2.1.1 perchlorate
-
 Mus musculus
4.2.1.1 phenylarsonic acid
-
 Mus musculus
4.2.1.1 phenylboronic acid
-
 Mus musculus
4.2.1.1 sulfamate
-
 Mus musculus
4.2.1.1 sulfamide
-
 Mus musculus
4.2.1.1 sulfate shows low micromolar inhibition against CA XV Mus musculus
4.2.1.1 thiocyanate shows low micromolar inhibition against CA XV Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.1 membrane
-
 Mus musculus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 CO2 + H2O
-
 Mus musculus H2CO3
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 Ca XV
-
 Mus musculus
4.2.1.1 carbonic anhydrase XV
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.1.1 0.0082
-
 bicarbonate isozyme CA XV Mus musculus
4.2.1.1 0.0085
-
 azide isozyme CA XV Mus musculus
4.2.1.1 0.0092
-
 hydrogen sulfide isozyme CA XV Mus musculus
4.2.1.1 0.0094
-
 cyanide isozyme CA XV Mus musculus
4.2.1.1 0.0095
-
 sulfate isozyme CA XV Mus musculus
4.2.1.1 0.0097
-
 hydrogen sulfite isozyme CA XV Mus musculus
4.2.1.1 0.0101
-
 thiocyanate isozyme CA XV Mus musculus
4.2.1.1 0.0276
-
 cyanide isozyme CA XV Mus musculus
4.2.1.1 0.0374
-
 sulfamide isozyme CA XV Mus musculus
4.2.1.1 0.0544
-
 fluoride isozyme CA XV Mus musculus
4.2.1.1 0.0612
-
 nitrite isozyme CA XV Mus musculus
4.2.1.1 0.0678
-
 phenylboronic acid isozyme CA XV Mus musculus
4.2.1.1 0.0682
-
 phenylarsonic acid isozyme CA XV Mus musculus
4.2.1.1 0.0687
-
 nitrate isozyme CA XV Mus musculus
4.2.1.1 0.0853
-
 chloride isozyme CA XV Mus musculus
4.2.1.1 0.0986
-
 sulfamate isozyme CA XV Mus musculus
4.2.1.1 0.104
-
 bromide isozyme CA XV Mus musculus
4.2.1.1 0.106
-
 Carbonate isozyme CA XV Mus musculus
4.2.1.1 0.288
-
 Iodide isozyme CA XV Mus musculus