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Literature summary extracted from

  • Kapur, S.; Worthington, A.; Tang, Y.; Cane, D.E.; Burkart, M.D.; Khosla, C.
    Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase (2008), Bioorg. Med. Chem. Lett., 18, 3034-3038.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.94 the ACP construct is engineered with the FLAG epitope Saccharopolyspora erythraea

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.94 10000
-
 ACP domain Saccharopolyspora erythraea
2.3.1.94 90000
-
 crosslinked ketosynthase3-acyltransferase3-ACP3 and ketosynthase5-acyltransferase5-ACP5 domains, determined by SDS-PAGE Saccharopolyspora erythraea

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.94 propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ Saccharopolyspora erythraea
-
 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.94 Saccharopolyspora erythraea
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.94
-
 Saccharopolyspora erythraea

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.94 propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+
-
 Saccharopolyspora erythraea 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.94 6-deoxyerythronolide B synthase
-
 Saccharopolyspora erythraea
2.3.1.94 DEBS
-
 Saccharopolyspora erythraea
2.3.1.94 PKS
-
 Saccharopolyspora erythraea
2.3.1.94 polyketide synthase
-
 Saccharopolyspora erythraea