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Literature summary extracted from

  • Kimura, M.; Kim, E.; Kang, W.; Yamashita, M.; Saigo, M.; Yamazaki, T.; Nakanishi, T.; Kashiwabara, S.; Baba, T.
    Functional roles of mouse sperm hyaluronidases, HYAL5 and SPAM1, in fertilization (2009), Biol. Reprod., 81, 939-947.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.1.35 52000
-
 SPAM1 Mus musculus
3.2.1.35 55000
-
 HYAL5 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.35 hyaluronan + 2 H2O Mus musculus
-
 N-acetyl-beta-D-glucosamine + D-glucuronate + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.35 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.35 sperm
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.35 hyaluronan + 2 H2O
-
 Mus musculus N-acetyl-beta-D-glucosamine + D-glucuronate + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.35 HYAL5
-
 Mus musculus
3.2.1.35 hyaluronidase-5
-
 Mus musculus
3.2.1.35 SPAM1
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.2.1.35 malfunction HYAL5-deficient epididymal sperm is functionally normal, the loss of SPAM1 results in a remarkably increased accumulation of sperm on the surface or outer edge of the cumulus Mus musculus
3.2.1.35 physiological function SPAM1 is involved in sperm penetration through the cumulus matrix Mus musculus