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Literature summary extracted from

  • Kandeel, M.; Miyamoto, T.; Kitade, Y.
    Bioinformatics, enzymologic properties, and comprehensive tracking of Plasmodium falciparum nucleoside diphosphate kinase (2009), Biol. Pharm. Bull., 32, 1321-1327.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.4.6 expressed in Escherichia coli JM109 cells Plasmodium falciparum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.4.6 0.42
-
dTDP
-
Plasmodium falciparum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.4.6 Mg2+ the presence of Mg2+ enhances enthalpy changes by stabilizing water molecule hydrogen bonding network, resulting in favorable enthalpy changes, the absence of Mg2+ induces a noticeable loss in binding enthalpies and positive favorable entropic changes in GDP binding, indicating a more unstable enzyme-ligand complex formation and lesser complex tightening Plasmodium falciparum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.4.6 18000
-
SDS-PAGE Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.6 ATP + NDP Plasmodium falciparum
-
ADP + NTP
-
?
2.7.4.6 ATP + NDP Plasmodium falciparum FCR-3
-
ADP + NTP
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.6 Plasmodium falciparum
-
-
-
2.7.4.6 Plasmodium falciparum FCR-3
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.4.6 Talon metal affinity resin column chromatography and Sephacryl S300 gel filtration Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.6 ATP + dTDP
-
Plasmodium falciparum ADP + dTTP
-
?
2.7.4.6 ATP + dTDP
-
Plasmodium falciparum FCR-3 ADP + dTTP
-
?
2.7.4.6 ATP + GDP
-
Plasmodium falciparum ADP + GTP
-
?
2.7.4.6 ATP + GDP
-
Plasmodium falciparum FCR-3 ADP + GTP
-
?
2.7.4.6 ATP + NDP
-
Plasmodium falciparum ADP + NTP
-
?
2.7.4.6 ATP + NDP
-
Plasmodium falciparum FCR-3 ADP + NTP
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.4.6 NDK
-
Plasmodium falciparum
2.7.4.6 nucleoside diphosphate kinase
-
Plasmodium falciparum
2.7.4.6 nucleoside diphosphate phosphotransferase
-
Plasmodium falciparum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.4.6 25 42
-
Plasmodium falciparum

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.7.4.6 50 70 enzyme activity is decreased by 70% at 50°C and completely lost after preincubation at 60°C, irreversible loss of activity is detected after treating the samples at temperatures above 70°C Plasmodium falciparum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.4.6 7 7.2
-
Plasmodium falciparum

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.4.6 6 9
-
Plasmodium falciparum

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.7.4.6 7.5 9 the activity markedly drops as pH exceeds 7.8, about 25% relative activity at pH8.0-9.0 Plasmodium falciparum

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.4.6 ATP
-
Plasmodium falciparum