Literature summary extracted from

Bellocchi, D.; Macchiarulo, A.; Carotti, A.; Pellicciari, R.
Quantum mechanics/molecular mechanics (QM/MM) modeling of the irreversible transamination of L-kynurenine to kynurenic acid: the round dance of kynurenine aminotransferase II (2009), Biochim. Biophys. Acta, 1794, 1802-1812.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.6.1.7	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.6.1.7	L-kynurenine + 2-oxobutyrate	-	Homo sapiens	kynurenic acid + 2-aminobutanoate + H2O	-	?

Subunits

EC Number	Subunits	Comment	Organism
2.6.1.7	homodimer	x-ray crystallography	Homo sapiens

Synonyms

EC Number	Synonyms	Comment	Organism
2.6.1.7	KAT-II	isoform	Homo sapiens
2.6.1.7	kynurenine aminotransferase II	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.6.1.7	pyridoxal 5'-phosphate	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
2.6.1.7	physiological function	KAT-II is the enzymatic isoform that mainly accounts for the synthesis of cerebral kynurenic acid	Homo sapiens

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Release 2023.1 (January 2023)