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Literature summary extracted from

  • Yoshida, T.; Kadota, Y.; Hitaoka, S.; Kori, E.; Horikawa, Y.; Taguchi, M.; Tsuji, D.; Hirokawa, T.; Chuman, H.; Itoh, K.
    Expression and molecular dynamics studies on effect of amino acid substitutions at Arg344 in human cathepsin A on the protein local conformation (2009), Biochim. Biophys. Acta, 1794, 1693-1699.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.16.5 expressed in T-1 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.16.5 R344A the mutant shows about wild type cathepsin A activity Homo sapiens
3.4.16.5 R344D inactive mutant, the 54 kDa precursor/zymogen with the R344D substitution is not processed to the 32/20 kDa mature form with CathA activity Homo sapiens
3.4.16.5 R344E the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens
3.4.16.5 R344G the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens
3.4.16.5 R344I the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens
3.4.16.5 R344K the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens
3.4.16.5 R344M the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens
3.4.16.5 R344N the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens
3.4.16.5 R344P the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens
3.4.16.5 R344Q the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens
3.4.16.5 R344S the mutant shows about wild type cathepsin A activity Homo sapiens
3.4.16.5 R344V the mutant shows reduced cathepsin A activity compared to the wild type Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.16.5 32000
-
 mature enzyme, SDS-PAGE Homo sapiens
3.4.16.5 54000
-
 proenzyme, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.16.5 Homo sapiens P10619
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.16.5 fibroblast
-
 Homo sapiens
-
3.4.16.5 fibroblast cell line from a galactosialidosis patient transformed with simian virus-40-adenovirus recombinant Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.16.5 benzyloxycarbonyl-L-Phe-L-Leu + H2O
-
 Homo sapiens benzyloxycarbonyl-L-Phe + L-Leu
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.16.5 carboxypeptidase Y
-
 Homo sapiens
3.4.16.5 CathA
-
 Homo sapiens
3.4.16.5 cathepsin A
-
 Homo sapiens
3.4.16.5 CPY
-
 Homo sapiens
3.4.16.5 EC 3.4.16.1 formerly Homo sapiens
3.4.16.5 lysosomal protective protein
-
 Homo sapiens