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Literature summary extracted from

  • Marinho-Carvalho, M.M.; Costa-Mattos, P.V.; Spitz, G.A.; Zancan, P.; Sola-Penna, M.
    Calmodulin upregulates skeletal muscle 6-phosphofructo-1-kinase reversing the inhibitory effects of allosteric modulators (2009), Biochim. Biophys. Acta, 1794, 1175-1180.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.11 ADP
-
 Oryctolagus cuniculus
2.7.1.11 Calmodulin binding of one calmodulin per monomer promotes the dimerization of the enzyme although maintaining its full catalytic activity, 30 nM calmodulin activates 6-phosphofructo-1-kinase in the presence of its inhibitors citrate and lactate Oryctolagus cuniculus
2.7.1.11 D-fructose 2,6-bisphosphate
-
 Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.11 ATP the inhibition of enzyme activity by ATP (above 1 mM) is abolished in the presence of calmodulin Oryctolagus cuniculus
2.7.1.11 citrate
-
 Oryctolagus cuniculus
2.7.1.11 Lactate
-
 Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.11 Ca2+ calmodulin binding to the enzyme is stimulated by 0.01 mM Ca2+ Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.11 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.11 skeletal muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.11 ATP + D-fructose 6-phosphate
-
 Oryctolagus cuniculus ADP + D-fructose 1,6-bisphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.11 dimer calmodulin-bound dimers are active and less susceptible to inhibition by allosteric ligands, 5 mM ATP stabilizes phosphofructokinase dimers Oryctolagus cuniculus

Synonyms

EC Number Synonyms Comment Organism
2.7.1.11 6-phosphofructo-1-kinase
-
 Oryctolagus cuniculus
2.7.1.11 ATP:D-fructose-6-phosphate-1-phosphotransferase
-
 Oryctolagus cuniculus
2.7.1.11 PFK
-
 Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.11 ATP
-
 Oryctolagus cuniculus