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Literature summary extracted from

  • Topham, M.K.; Epand, R.M.
    Mammalian diacylglycerol kinases: molecular interactions and biological functions of selected isoforms (2009), Biochim. Biophys. Acta, 1790, 416-424.
    View publication on PubMedView publication on EuropePMC

General Stability

EC Number General Stability Organism
2.7.1.107 DGKalpha is also activated when it binds to membranes Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.107 phosphatidylinositol 4,5-bisphosphate potent inhibitor Mus musculus
2.7.1.107 phosphatidylinositol-(4,5)-bisphosphate potent inhibitor; potent inhibitor Mus musculus
2.7.1.107 R59949 DGKalpha inhibitor Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.107 cytoplasm in the basal state, DGKzeta resides in the cytoplasm, but upon appropriate cellular events, it translocates to different parts of the cell in order to perform its biological role Mus musculus 5737
-
2.7.1.107 cytoskeleton
-
 Mus musculus 5856
-
2.7.1.107 nucleus
-
 Mus musculus 5634
-
2.7.1.107 plasma membrane
-
 Mus musculus 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.107 Ca2+ activates Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.107 64000
-
 isoform DGKepsilon Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.107 Mus musculus O88673 DGKalpha isoform
-
2.7.1.107 Mus musculus Q80UP3 DGKzeta isoform
-
2.7.1.107 Mus musculus Q9R1C6 DGKepsilon isoform
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.107 ATP + 1,2-diacylglycerol
-
 Mus musculus ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 ATP + 1,2-diacylglycerol DGKepsilon exhibits specificity for diacylglcerol substrates containing an arachidonoyl chain in the sn-2 position Mus musculus ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.107 DGKalpha isoform Mus musculus
2.7.1.107 DGKepsilon isoform Mus musculus
2.7.1.107 DGKzeta isoform Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.107 ATP
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.1.107 physiological function DGKalpha has a central role in modulating T cell anergy through its ability to control DAG levels, which likely activates RasGRP1 and possibly other proteins Mus musculus
2.7.1.107 physiological function DGKzeta has an important biological function in the nucleus where it appears to modulate the cell cycle by metabolizing 1,2-diacylglycerol Mus musculus