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Literature summary extracted from

  • Berdiaki, A.; Nikitovic, D.; Tsatsakis, A.; Katonis, P.; Karamanos, N.K.; Tzanakakis, G.N.
    bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells (2009), Biochim. Biophys. Acta, 1790, 1258-1265.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.35 hyaluronan + 2 H2O Homo sapiens
-
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.212 Homo sapiens Q92839 isoform HAS1
-
3.2.1.35 Homo sapiens Q12794
-
-
3.2.1.35 Homo sapiens Q12891
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.212 HT-1080 cell
-
Homo sapiens
-
3.2.1.35 HT-1080 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.35 hyaluronan + 2 H2O
-
Homo sapiens N-acetyl-beta-D-glucosamine + D-glucuronate + ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.35 HYAL1 isoform Homo sapiens
3.2.1.35 Hyal2 isoform Homo sapiens
3.2.1.35 hyaluronidase-1 isoform Homo sapiens
3.2.1.35 hyaluronidase-2 isoform Homo sapiens

Expression

EC Number Organism Comment Expression
2.4.1.212 Homo sapiens basic fibroblast growth factor bFGF increases HA-synthase-1 and -2 expression and enhances high molecular weight hyaluronan deposition in the pericellular matrix up
3.2.1.35 Homo sapiens basic fibroblast growth factor decreases hyaluronidase-2 expression in HT-1080 cells down

General Information

EC Number General Information Comment Organism
2.4.1.212 physiological function mainly high molecular weight hyaluronan synthesized by isoform HAS1 regulates HT-1080 cell motility Homo sapiens