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Literature summary extracted from

  • Tang, K.H.; Mansoorabadi, S.O.; Reed, G.H.; Frey, P.A.
    Radical triplets and suicide inhibition in reactions of 4-thia-D- and 4-thia-L-lysine with lysine 5,6-aminomutase (2009), Biochemistry, 48, 8151-8160.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.3.3 4-thia-D-lysine suicide inhibitor Porphyromonas gingivalis
5.4.3.3 4-thia-L-lysine suicide inhibitor Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.3.3 (3S)-3,6-diaminohexanoate Porphyromonas gingivalis
-
 (3S,5S)-3,5-diaminohexanoate
-
 ?
5.4.3.3 D-lysine Porphyromonas gingivalis
-
 2,5-diaminohexanoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.4.3.3 Porphyromonas gingivalis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.4.3.3
-
 Porphyromonas gingivalis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.3.3 (3S)-3,6-diaminohexanoate
-
 Porphyromonas gingivalis (3S,5S)-3,5-diaminohexanoate
-
 ?
5.4.3.3 4-thia-D-lysine substrate analogue, suicide inhibitor Porphyromonas gingivalis ?
-
 ?
5.4.3.3 4-thia-L-lysine substrate analogue, suicide inhibitor Porphyromonas gingivalis ?
-
 ?
5.4.3.3 D-lysine
-
 Porphyromonas gingivalis 2,5-diaminohexanoate
-
 ?
5.4.3.3 D-lysine
-
 Porphyromonas gingivalis D-2,5-diaminohexanoate
-
 ?
5.4.3.3 L-beta-lysine
-
 Porphyromonas gingivalis L-3,5-diaminohexanoate
-
 ?
5.4.3.3 L-lysine
-
 Porphyromonas gingivalis L-2,5-diaminohexanoate
-
 ?

Subunits

EC Number Subunits Comment Organism
5.4.3.3 heterotetramer alpha2beta2 Porphyromonas gingivalis

Synonyms

EC Number Synonyms Comment Organism
5.4.3.3 5,6-LAM
-
 Porphyromonas gingivalis
5.4.3.3 lysine 5,6-aminomutase
-
 Porphyromonas gingivalis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.4.3.3 37
-
 enzyme assay Porphyromonas gingivalis

Cofactor

EC Number Cofactor Comment Organism Structure
5.4.3.3 5'-deoxyadenosylcobalamin
-
 Porphyromonas gingivalis
5.4.3.3 pyridoxal 5'-phosphate
-
 Porphyromonas gingivalis

General Information

EC Number General Information Comment Organism
5.4.3.3 metabolism lysine 5,6-aminomutase participates in the fermentation of L- or D-lysine as carbon and nitrogen sources in anaerobic bacteria Porphyromonas gingivalis